{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:56:28Z","timestamp":1786114588212,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the psychometric properties of the Testicular Health Outcomes Report (THOR) tool by assessing associations of disease burden and treatment received with health\u2010related quality of life (HRQoL) domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>THOR, which comprises 26 questions across 14 HRQoL domains, was administered electronically to patients presenting for known or suspected testicular cancer prior to clinical visits and throughout their care longitudinally. We evaluated construct validity by determining whether related constructs showed better correlation with disease and treatment burden than unrelated constructs. Generalised estimating equations were used for each domain or predictor of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between August 2022 and November 2024, 709 patients completed 906 surveys. More aggressive post\u2010orchiectomy treatment \u2013 such as retroperitoneal lymph node dissection (RPLND), chemotherapy or post\u2010chemotherapy RPLND \u2013 was associated with worse sexual function and problems with job\/education. Patients undergoing nerve\u2010sparing RPLND reported significantly better sexual function (22 points, 95% confidence interval 11, 33;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) as compared to a non\u2010nerve\u2010sparing RPLND approach. Receipt of chemotherapy was associated with lower fertility confidence vs surveillance or primary RPLND (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005). Psychosocial domain scores and concern about disease relapse improved with time (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, concern about relapse was not associated with initial clinical stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The THOR survey instrument is a valid measure of symptom burden and treatment received in men with testicular cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70068","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:45:07Z","timestamp":1762307107000},"page":"289-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of the Testicular Health Outcomes Report (\n                    <scp>THOR<\/scp>\n                    ): a testicular cancer health\u2010related quality of life instrument"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-3938","authenticated-orcid":false,"given":"Samuel A.","family":"Gold","sequence":"first","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Tin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viranda H.","family":"Jayalath","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady","family":"Baky","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer 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