{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:39:24Z","timestamp":1789673964892,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To present a novel technique for cystoscopic application of RADA16, a self\u2010assembling peptide that promotes both haemostasis and healing within the irradiated bladder, and describe its efficacy for intractable haematuria from radiation cystitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 15 patients who had failed standard treatment for haematuria from radiation cystitis were offered this novel treatment at Guy's Hospital, London and Cleveland Clinic London, UK between February and October 2024. A standard saline cystoscopy was performed under general anaesthetic and the bladder emptied. CO\n                      <jats:sub>2<\/jats:sub>\n                      insufflation of the bladder was performed and the RADA16 deployed over the area of radiation telangiectasia. This was left for 5\u2009min and then the gas evacuated from the bladder. Patients were followed up for a minimum of 3\u2009months for complications and re\u2010bleeding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 14 of the 15 patients had significant reduction in their bleeding at 6\u2009weeks. One patient with ongoing bleeding proceeded to salvage cystectomy. Two patients required further cystodiathermy and RADA16 application within 3\u2009months. No other modified Clavien\u2013Dindo \u2265III complications occurred within 3\u2009months. Patients who had a follow\u2010up cystoscopy within 3\u2009months of application showed significant regression of the radiation\u2010induced telangiectasia with no evidence of bladder scarring or ureteric orifice obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cystoscopic application of RADA16 shows promise for treating intractable haematuria from radiation cystitis. It is the first treatment option that potentially provides both haemostasis as well as promoting bladder healing and regression of radiation\u2010induced telangiectasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70075","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:50:34Z","timestamp":1764291034000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cystoscopic application of\n                    <scp>RADA16<\/scp>\n                    peptide for refractory haematuria from radiation cystitis"],"prefix":"10.1111","volume":"137","author":[{"given":"Jonathan","family":"Kam","sequence":"first","affiliation":[{"name":"Department of Urology Guy's Hospital  London UK"},{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Nepean Urology Research Group  Sydney New South Wales 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