{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:38:19Z","timestamp":1787243899671,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterise 3\u2010year pelvic pain and urinary symptom trajectories and to identify baseline factors associated with urologic chronic pelvic pain syndrome (UCPPS) improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The Trans\u2010Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Symptom Patterns Study was a multicentre, prospective cohort study of UCPPS, including interstitial cystitis\/bladder pain syndrome and chronic prostatitis\/chronic pelvic pain syndrome. Patients completed four weekly run\u2010in assessments, baseline visit, and quarterly visits up to 3\u2009years, providing clinical and patient\u2010reported data. A functional clustering approach, applied separately to Pelvic Pain Severity (PPS) and Urinary Symptom Severity (USS) longitudinal change scores, was used to generate symptom trajectory clusters dichotomised as Group 0 \u2018improvers\u2019 vs Groups 1\u20133 \u2018non\u2010improvers\u2019. Logistic regression models explored baseline factors associated with improvement and included run\u2010in period average and baseline scores to adjust for regression to the mean effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 545 patients (66% female) were followed for a median (interquartile range) of 34\u2009(23\u201335)\u2009months. Four trajectory clusters were identified for each of PPS and USS, consistent with moderate improvement (Group 0), slight improvement (Group 1), no change (Group 2), and slight worsening (Group 3). In all, 18% and 19% of patients were in the moderately improved PPS and USS groups, respectively, representing 30% of patients overall. Female sex, better sleep, and less opioid use were associated with PPS improvement (Group 0); younger age and baseline cystoscopic treatment were associated with USS improvement (Group 0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In all, 30% of patients with UCPPS demonstrated improvement in pain and\/or urinary symptoms over 3\u2009years. Baseline factors associated with improvement may represent markers of a milder or localised phenotype and\/or treatment effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70087","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:25:28Z","timestamp":1764667528000},"page":"312-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Urologic chronic pelvic pain syndrome 3\u2010year symptom trajectories: the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (\n                    <scp>MAPP)<\/scp>\n                    Symptom Patterns Study"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7402-5476","authenticated-orcid":false,"given":"Catherine S.","family":"Bradley","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Carver College of Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"You","sequence":"additional","affiliation":[{"name":"School of Statistics and Data Science Shanghai University of International Business and Economics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Afari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego School of Medicine  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Kreder","sequence":"additional","affiliation":[{"name":"Department Urology, Carver College of Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Krieger","sequence":"additional","affiliation":[{"name":"Department of Urology University of Washington School of Medicine  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Henry","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology) and Anesthesiology Washington University School of Medicine  St Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Lutgendorf","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, Obstetrics and Gynecology and Urology University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Naliboff","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at UCLA  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery Washington University School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tu","sequence":"additional","affiliation":[{"name":"Endeavor Health and Pritzker School of Medicine University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"McWilliams","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Cornell Medicine  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Richard","family":"Landis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.05.065"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2022.07.045"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24423"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.06.078"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80333-1"},{"key":"e_1_2_12_8_1","volume-title":"The Brief Pain Inventory: User Guide","author":"Cleeland C","year":"2009"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25400"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.011"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001505"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.11.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002438"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.04.070"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003394"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2022.2066536"},{"issue":"3","key":"e_1_2_12_18_1","first-page":"E92","article-title":"Prognostic factors for recent\u2010onset interstitial cystitis\/painful bladder syndrome","volume":"111","author":"Warren JW","year":"2013","journal-title":"BJU Int"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24104"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002756"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25363"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.70087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T21:14:55Z","timestamp":1785964495000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.70087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/bju.70087"],"URL":"https:\/\/doi.org\/10.1111\/bju.70087","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"2025-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}