{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:33:05Z","timestamp":1786635185840,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007568","name":"Urology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007568","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020400","name":"John Black Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Introduction and Objectives<\/jats:title>\n Luminal Index magnetic resonance imaging (LI\u2010MRI) is a novel technique that has recently been proposed for prostate cancer (PCa) characterisation. It is based on multi\u2010echo T2\u2010weighted sequences and requires <10\u2009min to be performed. However, evidence on its diagnostic performance in the diagnostic evaluation of PCa is lacking. The \u2018Comparison of diagnostic accuracy of Luminal Index and standard of care MRI for Accelerated deTEction of prostate cancer\u2019 (CLIMATE) trial aims to compare the diagnostic accuracy of LI\u2010MRI and standard of care (SOC) MRI (multiparametric or biparametric MRI) for the detection of clinically significant PCa (csPCa).<\/jats:p>\n <\/jats:sec>\n \n Trial Design<\/jats:title>\n The CLIMATE trial is a prospective, multicentre, paired, non\u2010randomised comparative trial of LI\u2010MRI and SOC MRI targeted biopsy in participants with clinically suspected PCa.<\/jats:p>\n <\/jats:sec>\n \n Endpoints<\/jats:title>\n The primary endpoint of the trial is to compare the per\u2010participant diagnostic accuracy of LI\u2010MRI and SOC MRI for csPCa using targeted biopsies as the standard of reference.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n Adult men (aged \u226518\u2009years) with clinical suspicion of PCa and no prior PCa diagnosis or treatment will be invited. Each participant will undergo LI\u2010MRI and SOC MRI in a single scan session, with each test interpreted without knowledge of the other test images or results. LI\u2010MRI and SOC MRI will be reported on a 1\u20135 scale for suspicion of tumour (Likert scale or Prostate Imaging\u2010Reporting and Data System). Targeted biopsies will be taken for any suspicious lesions detected, defined as MRI score of \u22653.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n Registry (NCT05020522).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.70108","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:41:46Z","timestamp":1769413306000},"page":"611-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The \u2018Comparison of diagnostic accuracy of Luminal Index and standard of care\n MRI<\/scp>\n for Accelerated\n deTEction<\/scp>\n of prostate cancer\u2019 (CLIMATE) trial protocol"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-0545","authenticated-orcid":false,"given":"Tarek","family":"Al\u2010Hammouri","sequence":"first","affiliation":[{"name":"Centre of Medical Imaging University College London 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhardt","family":"Attard","sequence":"additional","affiliation":[{"name":"Cancer Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0202-7912","authenticated-orcid":false,"given":"Caroline","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Science University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonit","family":"Punwani","sequence":"additional","affiliation":[{"name":"Centre of Medical Imaging University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CLIMATE Trial Management 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