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We included patients with either GG1 PCa detected by systematic biopsies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093317) or GG2 PCa detected with targeted biopsies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009554) between 1993 and 2019. We assessed the risk of curative treatment and recurrence after treatment. Kaplan\u2013Meier curves were used to estimate treatment\u2010 and recurrence\u2010free survival, and Cox proportional hazards regression was used to evaluate the risk of post\u2010treatment recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with systematic biopsy\u2010detected GG1 cancer had a significantly longer median time to treatment (31\u2009months) than those with targeted biopsy\u2010detected GG2 cancer (4\u2009months;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Risk of recurrence after curative treatment was similar in the two groups, with the upper bound of the 95% confidence interval (CI) excluding any significant difference (hazard ratio 1.04, 95% CI 0.75\u20131.43;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.83).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Men diagnosed with GG2 PCa based on MRI\u2010targeted biopsy had a similar risk of recurrence after treatment compared to men with GG1 disease diagnosed using systematic biopsy, although they were more likely to undergo curative treatment. These findings suggest that at least a portion of the apparent increase in GG2 diagnoses in the MRI era may reflect reclassification rather than more aggressive disease. Improved risk stratification is needed to identify which men with MRI\u2010era GG2 cancer may be suitable for active surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70109","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:55:13Z","timestamp":1765781713000},"page":"547-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparable recurrence risk for\n                    <scp>MRI<\/scp>\n                    \u2010detected Gleason Grade Group (GG)\n                    <scp>2<\/scp>\n                    and systematic biopsy\u2010detected\n                    <scp>GG1<\/scp>\n                    prostate cancer"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-9891","authenticated-orcid":false,"given":"Abderrahim\u2010Oussama","family":"Batouche","sequence":"first","affiliation":[{"name":"Research Program 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