{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:33:35Z","timestamp":1786635215483,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Objectives<\/jats:title>\n \n To analyse the utility of adding multiparametric magnetic resonance imaging (mpMRI) with\n 68<\/jats:sup>\n Ga\u2010prostate\u2010specific membrane antigen (PSMA) positron emission tomography\/computed tomography (PET\/CT) in detection of local recurrence (LR) and distant recurrence (DR) in patients with biochemical recurrence (BCR), by describing detection rates over time since radical prostatectomy (RP), describing detection rates at differing prostate\u2010specific antigen (PSA) intervals, and identifying clinicopathological factors that predict detection of recurrence on imaging.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n Patients with BCR after RP were identified from 2016 to 2020. Kaplan\u2013Meier analysis was performed for LR and DR on mpMRI,\n 68<\/jats:sup>\n Ga\u2010PSMA PET\/CT, and paired\/combined scans, and multivariate regression was performed identifying predictors of LR and DR.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 117 patients underwent 150 sets of paired scans for BCR after RP, at PSA thresholds 0.2, 0.5, and 1.0\u2009ng\/mL. The\n 68<\/jats:sup>\n Ga\u2010PSMA PET\/CT had higher detection rates of DR at PSA levels of <0.2, 0.2\u20130.5, 0.5\u20131.0, and >1.0\u2009ng\/mL vs mpMRI (6.1%, 10%, 25% and 36% vs 3%, 6.7%, 6.3%, and 24%, respectively). Meanwhile, mpMRI had higher detection rate of LR than\n 68<\/jats:sup>\n Ga\u2010PSMA PET\/CT (30.3%, 33.3%, 40.6%, and 40% vs 0%, 13.3%, 18.8%, and 32%, respectively). The detection rate for LR was significantly higher on MRI compared to PSMA at PSA levels of <0.2 and 0.2\u20130.5\u2009ng\/mL (\n P<\/jats:italic>\n \u2009<\u20090.001 and\n P<\/jats:italic>\n \u2009=\u20090.001, respectively). The detection rate for DR was significantly higher on PSMA than MRI at PSA levels of 0.5\u20131.0\u2009ng\/mL (\n P<\/jats:italic>\n \u2009=\u20090.039). On multivariate analysis, PSA velocity was a statistically significant predictor of both LR and DR on MRI alone, PSMA alone, and combined results of paired PSMA and MRI, and International Society of Urological Pathology grade was a statistically significant predictor of DR on MRI.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The mpMRI had a higher detection rate for LR, while\n 68<\/jats:sup>\n Ga\u2010PSMA PET\/CT had a higher detection rate for DR. PSA velocity was a significant predictor of both LR and DR on both imaging modalities. In BCR after RP, addition of mpMRI with\n 68<\/jats:sup>\n Ga\u2010PSMA PET\/CT may improve diagnosis of recurrent lesions and patient selection for treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.70115","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T14:10:10Z","timestamp":1767881410000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does addition of multiparametric\n MRI<\/scp>\n to\n PSMA PET\/CT<\/scp>\n improve diagnostic accuracy for biochemical recurrence after radical prostatectomy?"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1747-5814","authenticated-orcid":false,"given":"Yash","family":"Khanna","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Nursing and Health Sciences Monash University Melbourne Victoria Australia"},{"name":"Monash Health Clayton Victoria 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Imaging Richmond Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita E.","family":"Ballok","sequence":"additional","affiliation":[{"name":"Lumus Imaging Richmond Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ryan","sequence":"additional","affiliation":[{"name":"TissuPath Mount Waverley Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakher","family":"Ramdave","sequence":"additional","affiliation":[{"name":"Monash Health Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Sivaratnam","sequence":"additional","affiliation":[{"name":"Cabrini Institute Cabrini Health Malvern Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bowden","sequence":"additional","affiliation":[{"name":"Icon Cancer Centre Richmond Victoria 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