{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:49:04Z","timestamp":1790606944075,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To present large\u2010scale safety outcomes, with a particular focus on postoperative bleeding following Aquablation for benign prostatic hyperplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients who underwent Aquablation between 2019 and 2024 across Asia, Europe, and North America were assessed to evaluate trends in treated prostate sizes, which were visualised using density plots. A corporate prospective database was maintained, incorporating case recordings and data collected by on\u2010site company representatives. In addition, the incidence of postoperative bleeding\u2014defined as transfusion or surgical takeback for haemostatic fulguration\u2014was analysed using data from the United States Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database and procedure counts by the manufacturer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 70\u2009270 Aquablation procedures were evaluated over the period from 2019 to 2024. The mean (standard deviation) prostate volume was 87.3\u2009(42.4)\u2009mL, with a maximum recorded size of 1189\u2009mL. Density plot analysis of prostate volumes demonstrated consistent utilisation of Aquablation across the full range of prostate sizes throughout all years studied. The overall rate of blood transfusion or return to the operating room for haemostatic fulguration was 0.2%, indicating a favourable safety profile across a very wide range of prostate sizes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aquablation has been consistently utilised across a broad spectrum of prostate sizes, with a low overall rate of transfusion or return to the operating room for bleeding control. These findings highlight the procedure's broad applicability and favourable safety profile in real\u2010world practice from 2019 to 2024.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70118","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T07:44:38Z","timestamp":1765871078000},"page":"480-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aquablation for benign prostatic hyperplasia: real\u2010world prostate size relevance and bleeding events across 6\u2009years"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2867-9723","authenticated-orcid":false,"given":"Mario","family":"Bitar","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-8433","authenticated-orcid":false,"given":"Roseanne","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagi","family":"Shprits","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Buksh","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-2635","authenticated-orcid":false,"given":"Naeem","family":"Bhojani","sequence":"additional","affiliation":[{"name":"Division of Urology Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Chughtai","sequence":"additional","affiliation":[{"name":"Smith Institute of Urology, Northwell Health Plainview Hospital  Syosset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Zorn","sequence":"additional","affiliation":[{"name":"BPH Canada Prostate Surgical Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-7783","authenticated-orcid":false,"given":"Dean","family":"Elterman","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2017.06.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.8638"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-024-04997-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.12.065"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"10610","article-title":"Focal bladder neck cautery associated with low rate of post\u2010Aquablation bleeding","volume":"28","author":"Elterman DS","year":"2021","journal-title":"Can J Urol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03390-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.06.024"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03137-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2024.08.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16272"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02959-5"},{"key":"e_1_2_8_13_1","first-page":"10072","article-title":"Three\u2010year outcomes after Aquablation therapy compared to TURP: results from a blinded randomized trial","volume":"27","author":"Gilling P","year":"2020","journal-title":"Can J Urol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14360"},{"key":"e_1_2_8_15_1","first-page":"10691","article-title":"Aquablation and question of hemostasis","volume":"28","author":"Menon A","year":"2021","journal-title":"Can J Urol"},{"key":"e_1_2_8_16_1","unstructured":"U.S. Food and Drug Administration.Medical device report: MDR 3012977056\u20102025\u201000008 \u2013 hematuria following Aquablation procedure. [Internet]. Silver Spring MD: FDA 2025."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14990"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020603"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2013.0805"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072171"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16304"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.20210297"},{"key":"e_1_2_8_23_1","first-page":"10884","article-title":"Men with lower urinary tract symptoms secondary to BPH undergoing Aquablation with very large prostates (>150 mL)","volume":"28","author":"Helfand BT","year":"2021","journal-title":"Can J Urol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","unstructured":"RitterM SteinJ BarberNet\u00a0al.WATER III: Aquablation vs. Transurethral Laser Enucleation of Large Prostates (80\u2013180 ml) in Benign Prostatic Hyperplasia. Presented at 40th Annual European Association of Urology Congress. Madrid Spain. March 21\u201324 2025.","DOI":"10.1016\/S0302-2838(26)01460-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24810"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsit-2021-000090"},{"key":"e_1_2_8_27_1","first-page":"10960","article-title":"Five\u2010year outcomes for Aquablation therapy compared to TURP: results from a double\u2010blind, randomized trial in men with LUTS due to BPH","volume":"29","author":"Gilling PJ","year":"2022","journal-title":"Can J Urol"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.70118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:58:18Z","timestamp":1773316698000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.70118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/bju.70118"],"URL":"https:\/\/doi.org\/10.1111\/bju.70118","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}