{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:01:19Z","timestamp":1784847679180,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the short\u2010term oncological results and safety of the ProFocal Laser Therapy for Prostate Tissue Ablation (PFLT\u2010PC) trial, the first phase II clinical trial of ProFocal\u00ae (Medlogical Innovations, Sydney, Australia), a novel, cooled laser focal therapy (cLFT) device for prostate cancer (PCa) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Men with localised PCa, prostate\u2010specific antigen (PSA) level \u226415\u2009ng\/mL, T stage \u2264T2c, International Society of Urological Pathology (ISUP) score 2\u20133 concordant with multiparametric magnetic resonance imaging (mpMRI) visible\u00a0disease were recruited for this trial (Australian and New Zealand Clinical Trial Registry [ACTRN]12618001774213p) at Nepean Hospital, Australia. The cLFT was performed under general anaesthesia as a day procedure. Primary outcome was adequacy of tissue ablation assessed by mpMRI within 72\u2009h and biopsy at 3\u2009months. Secondary outcomes of functional measures were assessed using validated questionnaires (International Prostate Symptom Score, Sexual Health Inventory for Men [SHIM], Expanded Prostate cancer Index Composite [EPIC], 12\u2010item Short\u2010Form Health Survey). Complications and adverse events within 90\u2009days were reported using Clavien\u2013Dindo classification grading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 100 patients were recruited. The median (interquartile range [IQR]) age was 66\u2009(60\u201372)\u2009years, PSA level 5.9\u2009(3.9\u20137.6)\u2009ng\/mL, prostate volume 39\u2009(30\u201351)\u2009mL and MRI lesion volume 0.84\u2009(0.57\u20131.2)\u2009mL. The median (IQR) treatment time was 60\u2009(47\u201370)\u2009min. In all, 84% had no ISUP Grade Group \u22652 PCa in their 3\u2010month treatment zone biopsies. Erectile dysfunction was reported in 12% of the men, with a 15% mean decline in the SHIM and EPIC\u2010sexual domains scores. There was a 4.5% decrease on EPIC\u2010urinary domain scores. There was no decline in any\u00a0other functional measures. This study's main limitations were the absence of a control group and the short follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PFLT\u2010PC trial demonstrates that at 3\u2009months, cLFT using the ProFocal device provides an 84% treatment success with low morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70150","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:03:27Z","timestamp":1769587407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Focal therapy using a novel cooled laser device for prostate cancer: early trial results"],"prefix":"10.1111","volume":"138","author":[{"given":"Jonathan","family":"Kam","sequence":"first","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"Nepean Hospital  Kingswood New South Wales Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishoy","family":"Hanna","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Jackson","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McCombie","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"Fiona Stanley Hospital  Murdoch Western Australia Australia"},{"name":"UWA Medical School University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"McClintock","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"Department of Urology Royal Brisbane Women's Hospital  Brisbane Queensland Australia"},{"name":"UQ Centre for Clinical Research University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Rahkala","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Teoh","sequence":"additional","affiliation":[{"name":"S.H. 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