{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:52:32Z","timestamp":1776070352326,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014195","name":"Region V\u00e4rmland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014195","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report descriptive outcomes including prostate\u2010specific antigen (PSA) testing, diagnostic activity and diagnostic outcomes during the initial 5\u2009years of a regional mailed PSA information and testing programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Between 2015 and 2019 a letter regarding the pros and cons of PSA testing was sent to all men in the V\u00e4rmland region of Sweden in every fifth year age group between 50 and 70\u2009years. A total of 44\u2009530 men were informed and instructed to contact their primary care centre if they wished to have a PSA test. Men with a PSA level \u22653\u2009\u03bcg\/L were referred to a urologist for evaluation. We used local and national registers to report trends in PSA testing, diagnostic activity, and diagnostic outcomes after programme implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An average of 20% of informed men had a PSA test within 6\u2009months, with increasing proportions over time. Among informed men, 3.5% had a PSA level \u22653\u2009\u03bcg\/L, 3.6% had a urology consultation, 1.5% underwent biopsies, and 0.8% were diagnosed with prostate cancer. [Correction added on 26 February 2026, after first online publication: The word \u2018tested\u2019 has been corrected to \u2018informed\u2019 in the preceding sentence.] The proportion who underwent magnetic resonance imaging was low. Between 2014 and 2017, the yearly number of PSA\u2010tested men in the region increased from 4800 to 11\u2009800 and the number of men undergoing prostate biopsies increased from 772 to 1217. Yearly prostate cancer incidence in the age group 50\u201374\u2009years increased from 386 (2010\u20132013) to 659 cases\/100\u2009000 (2016\u20132019). We observed an increase mainly among intermediate\u2010 and low\u2010risk tumours. At the end of the period, 80% of men in the older\u2010age groups had had a PSA test during the preceding years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Organising a population\u2010based mailed PSA information programme combined with accessible testing in primary care is feasible on a regional scale in a Scandinavian healthcare setting and may reach high attendance. An observed increase in low\u2010risk tumours inspires caution against programme implementation and highlights the importance of well\u2010designed screening strategies and diagnostic algorithms to avoid over\u2010detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70180","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:54:41Z","timestamp":1771419281000},"page":"877-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The 5\u2010year outcomes of a regional population\u2010based\n                    <scp>PSA<\/scp>\n                    information and testing programme"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-5300","authenticated-orcid":false,"given":"Henrik","family":"Ugge","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health \u00d6rebro University Hospital  \u00d6rebro Sweden"},{"name":"School of Medical Sciences \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Daouacher","sequence":"additional","affiliation":[{"name":"School of Medical Sciences \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Department of Urology Central Hospital of Karlstad  Karlstad Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauritz","family":"Wald\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Urology Central Hospital of Karlstad  Karlstad Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Statistik om cancer \u2010 Socialstyrelsen. 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