{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:52:17Z","timestamp":1776070337134,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the prognostic impact of T\u2010stage at re\u2010transurethral resection of bladder (TURB) and its utility for refining risk stratification across European Association of Urology 2021 (EAU21) risk groups in patients with T1 high\u2010grade (HG) non\u2010muscle\u2010invasive bladder cancer (NMIBC) treated with adequate Bacillus Calmette\u2013Gu\u00e9rin (BCG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Retrospective multicentre study including patients with primary or secondary T1HG NMIBC treated with TURB, re\u2010TURB, and adequate BCG between 2007 and 2020 across 28 European academic centres. Patients were stratified according to re\u2010TURB pathological stage (T0, Ta, Tis, T1) and EAU21 risk groups. Kaplan\u2013Meier, Cox regression, and competing\u2010risk methods were used to evaluate recurrence\u2010free survival (RFS), HG\u2010RFS, progression\u2010free survival (PFS), and cancer\u2010specific mortality (CSM). A mixture cure model estimated statistical cure fractions for the overall cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1403 patients, residual disease at re\u2010TURB was identified in 38.8%, including 17.7% with persistent T1. Residual T1 was consistently associated with worse outcomes. Compared with T0\/Ta, persistent T1 at re\u2010TURB showed substantially lower 5\u2010year HG\u2010RFS and PFS, with high\u2010grade recurrence in over half of patients and 5\u2010year progression up to 48% in high\u2010 and very high\u2010risk groups. The 5\u2010year CSM rose from 6\u20137% (T0\/Ta) to 23% (T1). On multivariable analysis, residual T1 was independently associated with worse HG\u2010RFS (hazard ratio 2.40), PFS (hazard ratio 3.10), and CSM (hazard ratio 3.00). Cure modelling showed lower cure fractions for residual T1 compared with T0\/Ta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Residual T1 at re\u2010TURB is strongly associated with adverse long\u2010term oncological outcomes in BCG\u2010treated T1HG NMIBC and markedly reduces the likelihood of statistical cure. High\u2010 and very high\u2010risk patients with persistent T1 represent a biologically adverse subgroup in whom standard BCG may be insufficient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70207","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:33:48Z","timestamp":1772969628000},"page":"866-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of re\u2010transurethral resection of bladder staging on risk stratification of high\u2010grade\n                    <scp>T1<\/scp>\n                    non\u2010muscle\u2010invasive bladder cancer across European Association of Urology 2021 risk groups"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7149-0578","authenticated-orcid":false,"given":"Ana","family":"Fern\u00e1ndez\u2010Mardomingo","sequence":"first","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4176-8174","authenticated-orcid":false,"given":"Jose Daniel","family":"Subiela","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-0344","authenticated-orcid":false,"given":"Alberto","family":"Artiles Medina","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Krajewski","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Robotic Urology, Center of Excellence in Urology Wroc\u0142aw Medical University  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-9048","authenticated-orcid":false,"given":"Renate","family":"Pichler","sequence":"additional","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Innsbruck Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils C. H.","family":"van Creij","sequence":"additional","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Innsbruck Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de la Palma","family":"de la Estella Lucena","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"de la Parra","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"M\u00ednguez Ojeda","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"Coloma","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Crespo Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Del Olmo Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5853-8845","authenticated-orcid":false,"given":"Daniel A.","family":"Gonz\u00e1lez\u2010Padilla","sequence":"additional","affiliation":[{"name":"Department of Urology Cl\u00ednica Universidad de Navarra  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Villacampa","sequence":"additional","affiliation":[{"name":"Department of Urology Cl\u00ednica Universidad de Navarra  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia","family":"Aumatell","sequence":"additional","affiliation":[{"name":"Servicio de Urolog\u00eda, Hospital Universitario Rey Juan Carlos Universidad Rey Juan Carlos M\u00f3stoles  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Scilipoti","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, Department of Urology, Urological Research Institute Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Longoni","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, Department of Urology, Urological Research Institute Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3084-2458","authenticated-orcid":false,"given":"Marco","family":"Moschini","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, Department of Urology, Urological Research Institute Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0494-7839","authenticated-orcid":false,"given":"Mario","family":"de Angelis","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, Department of Urology, Urological Research Institute Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Ca\u00f1o\u2010Velasco","sequence":"additional","affiliation":[{"name":"Department of Urology Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-0537","authenticated-orcid":false,"given":"Roberto","family":"Contieri","sequence":"additional","affiliation":[{"name":"Department of Urology Istituto Nazionale Tumori IRCCS Fondazione G. 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