{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:43:03Z","timestamp":1791931383834,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prostate\u2010specific antigen (PSA) testing and prostate cancer\u2010related outcomes in a national, publicly funded healthcare setting, with recommendations against testing of asymptomatic men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>All men born between 1920 and 1970, alive and residing in Denmark on 1 January 2014, were quarried in the national health registries. Age\u2010standardised rates (ASR) per 100\u2009000 men for men aged &gt;50\u2009years and cumulative incidence at 100\u2009years by Aalen Johansen estimator with delayed entry were estimated for PSA testing, prostate histology, biopsy, prostate cancer diagnosis, and prostate cancer\u2010specific death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1\u2009371\u2009099 eligible men, the ASR of PSA testing in 2023 was 14\u2009659 tests per 100\u2009000 men (95% confidence interval [CI] 14\u2009585\u201314\u2009733), and 21\u2009828 tests per 100\u2009000 men (95% CI 21\u2009646\u201322\u2009111) in men aged 70\u201379\u2009years. Cumulative incidence at 100\u2009years of a PSA test was 84% (95% CI 84\u201384%), prostate histology 20% (95% CI 20\u201320%), biopsy 15% (95% CI 15\u201315%), prostate cancer diagnosis 12% (95% CI 11\u201312%), and prostate cancer\u2010specific death 5.0% (95% CI 5.0\u20135.1%). The median (interquartile range [IQR]) age at initial PSA test was 60\u2009(52\u201367)\u2009years, 70\u2009(64\u201376)\u2009years at prostate histology and biopsy, 72\u2009(66\u201378)\u2009years at prostate cancer diagnosis, and 84\u2009(78\u201389)\u2009years at prostate cancer\u2010specific death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Denmark PSA testing rates are high and prevalent in older ages, despite restrictive national guidelines and active training against PSA testing for general practitioners. The findings support the discussion of whether the availability of the PSA test should be reconsidered to minimise the harms associated with unnecessary testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70208","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:47:49Z","timestamp":1772970469000},"page":"992-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prostate\u2010specific antigen testing and prostate cancer\u2010related outcomes: a Danish nationwide study"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-8460","authenticated-orcid":false,"given":"Frederik K.","family":"Palshof","sequence":"first","affiliation":[{"name":"Cancer and Medicine, Danish Cancer Institute, Danish Cancer Society  Copenhagen Denmark"},{"name":"Department of Breast Surgery Gentofte Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-2569","authenticated-orcid":false,"given":"Lina S.","family":"M\u00f8rch","sequence":"additional","affiliation":[{"name":"Cancer and Medicine, Danish Cancer Institute, Danish Cancer Society  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6562-6416","authenticated-orcid":false,"given":"Klaus","family":"Brasso","sequence":"additional","affiliation":[{"name":"Copenhagen Prostate Cancer Centre, Department of Urology Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6631-2993","authenticated-orcid":false,"given":"Niels","family":"Kroman","sequence":"additional","affiliation":[{"name":"Cancer and Medicine, Danish Cancer Institute, Danish Cancer Society  Copenhagen Denmark"},{"name":"Department of Breast Surgery Gentofte Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-7678","authenticated-orcid":false,"given":"Signe Benzon","family":"Larsen","sequence":"additional","affiliation":[{"name":"Cancer and Medicine, Danish Cancer Institute, Danish Cancer Society  Copenhagen Denmark"},{"name":"Copenhagen Prostate Cancer Centre, Department of Urology Rigshospitalet  Copenhagen Denmark"},{"name":"Section of Epidemiology, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-5333","authenticated-orcid":false,"given":"Andreas","family":"R\u00f8der","sequence":"additional","affiliation":[{"name":"Copenhagen Prostate Cancer Centre, Department of Urology Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7293-9506","authenticated-orcid":false,"given":"Hein V.","family":"Stroomberg","sequence":"additional","affiliation":[{"name":"Copenhagen Prostate Cancer Centre, Department of Urology Rigshospitalet  Copenhagen Denmark"},{"name":"Biotech Research &amp; 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