{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:14:52Z","timestamp":1778660092679,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the oncological outcomes of targeted microwave ablation (TMA) using organ\u2010based tracking (OBT) Fusion\u00ae via KOELIS Trinity\u00ae (KOELIS, Meylan, France) in men with intermediate\u2010risk prostate cancer (PCa): the VIOLETTE trial (ClinicalTrials.gov identifier: NCT04582656)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Method<\/jats:title>\n                    <jats:p>In this prospective phase II, multicentre European study, men with a prostate\u2010specific antigen (PSA) level &lt;20\u2009ng\/mL, a single magnetic resonance imaging (MRI)\u2010visible lesion \u226415\u2009mm, International Society of Urological Pathology (ISUP) Grade Group 2 on MRI\u2010targeted biopsy, and clinical T stage \u22642, were enrolled. The microwave applicator was placed using OBT Fusion guidance, either transperineally or transrectally. The primary endpoint was the absence of clinically significant PCa (csPCa), defined as ISUP Grade Group \u22652, within the treated area at 12\u2009months. Secondary endpoints included safety, functional outcomes using validated measures, and the need for subsequent radical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 76 patients were treated across six centres with 66 (87%) completing the 12\u2010month follow\u2010up. At 6\u2009months, six patients had csPCa after positive MRI control, including four within the treated area. At 12\u2009months, csPCa was detected in 15 additional patients, including nine in\u2010field recurrences, yielding an 81% in\u2010field csPCa\u2010free rate. Five serious adverse events in three patients were reported. Sexual (\u22122.5 points;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and ejaculatory (\u22121 points;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) scores decreased significantly, whereas urinary function remained stable. Radical treatment was required in four (5.2%) patients at 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Targeted microwave ablation using OBT Fusion technology appears to be a safe and effective focal therapy procedure for localised intermediate\u2010risk PCa. The VIOLETTE trial achieved its primary endpoint, with 81% patients free of in\u2010field csPCa at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70220","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:33:49Z","timestamp":1773225229000},"page":"1032-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted microwave ablation of localised prostate cancer (\n                    <scp>VIOLETTE trial<\/scp>\n                    ): a prospective multicentre study"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-9567","authenticated-orcid":false,"given":"Nicolas Barry","family":"Delongchamps","sequence":"first","affiliation":[{"name":"Department of Urology, H\u00f4pital Cochin, APHP Universit\u00e9 Paris Cit\u00e9  Paris 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