{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:05:42Z","timestamp":1780920342031,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010148","name":"Asociaci\u00f3n Espa\u00f1ola de Urolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010148","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the performance of a new digital Uromonitor\u00ae (dUM; U\u2010Monitor, Porto, Portugal) against the previous quantitative polymerase chain reaction (qPCR) version and cytology in the follow\u2010up of non\u2010muscle\u2010invasive bladder cancer (NMIBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective (\n                      <jats:italic>post hoc<\/jats:italic>\n                      ) molecular analysis of a prospectively collected multicentre cohort re\u2010analysed stored urine DNA samples from the \u2018External Validation of Uromonitor as a Biomarker for Optimization of NMIBC Management by the Club Urol\u00f3gico Espa\u00f1ol de Tratamiento Oncol\u00f3ggico Group\u2019 (EVALUATION\u2010CUETO) study (ClinicalTrials.gov identifier: NCT05864599). Samples, previously tested with Uromonitor\u2010version 2, were analysed using dUM (QX200\u2122 Droplet Digital PCR System) for\n                      <jats:italic>TERT<\/jats:italic>\n                      and\n                      <jats:italic>FGFR3<\/jats:italic>\n                      hotspot mutations. Performance metrics (sensitivity, specificity, positive predictive value [PPV], negative predictive value [NPV], area under the curve [AUC]) for detecting recurrence were calculated against cystoscopy\/histology and compared to qPCR and cytology. The study received approval from the Ethical Committee at the University Hospital of Vall d\u2019Hebron (Barcelona).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis of 271 samples revealed dUM had superior sensitivity to qPCR (72% vs 36%) and cytology (72% vs 34%), while preserving high specificity (88%) and NPV (93%). The AUC for dUM was 0.80 vs 0.66 for qPCR. Performance was consistent across tumour grades and risk groups. Crucially, combining a positive\/suspicious cystoscopy with a positive dUM result significantly increased the PPV to 94% (from 79% for cystoscopy alone).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The dUM significantly outperformed its qPCR predecessor and cytology in sensitivity for detecting NMIBC recurrence in a real\u2010world setting, without compromising specificity. Its high NPV supports its potential for reducing unnecessary cystoscopies. Furthermore, its combination with cystoscopy drastically increased the PPV, suggesting a role as an adjunctive tool to improve diagnostic confidence and potentially reduce unnecessary transurethral resections of bladder tumour, pending favourable cost\u2010effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70230","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T16:58:47Z","timestamp":1775494727000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Digital Uromonitor\u00ae outperforms quantitative polymerase chain reaction Uromonitor and cytology for non\u2010muscle\u2010invasive bladder cancer surveillance: results from the \u2018External Validation of Uromonitor as a Biomarker for Optimization of NMIBC Management by the Club Urol\u00f3gico Espa\u00f1ol de Tratamiento Oncol\u00f3gico Group\u2019\n                    <scp>(EVALUATION<\/scp>\n                    \u2010\n                    <scp>CUETO)<\/scp>\n                    study"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-4641","authenticated-orcid":false,"given":"Jose","family":"Rubio\u2010Briones","sequence":"first","affiliation":[{"name":"Hospital VITHAS 9 de Octubre, Urology  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-3465","authenticated-orcid":false,"given":"F\u00e9lix","family":"Guerrero Ramos","sequence":"additional","affiliation":[{"name":"Hospital 12 de Octubre, Urology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-2704","authenticated-orcid":false,"given":"Asier","family":"Mercad\u00e9 S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic, Urology  Barcelona 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