{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:19:45Z","timestamp":1791094785105,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To refine prostate cancer (PCa) pathways by comparing micro\u2010ultrasonography\u2010targeted biopsy (micro\u2010US\u2010TBx) with magnetic resonance imaging (MRI)\u2010TBx for detecting clinically significant PCa (csPCa) and by evaluating diagnostic accuracy (sensitivity, specificity, positive predictive value, negative predictive value).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The Medical Literature Analysis and Retrieval System Online (MEDLINE; PubMed), Excerpta Medica dataBASE (EMBASE), and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>\n                      were searched on 4 July 2025 and updated 5 August 2025, without language\/date limits. Eligible randomised and observational studies compared micro\u2010US\u2010TBx vs MRI\u2010TBx (\u00b1 systematic biopsy) in men with suspected PCa or on active surveillance; csPCa was Gleason Grade Group \u22652. Two reviewers screened\/extracted per the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses 2020 guidelines; quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies\u20102 tool. Detection ratios (DRs) were pooled with random\u2010effects models; diagnostic accuracy used a bivariate random\u2010effects model from 2\u2009\u00d7\u20092 tables. Certainty of evidence was rated with the Grading of Recommendations, Assessment, Development, and Evaluation framework.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 22 studies (micro\u2010US\u2010TBx\u2009=\u20095581; MRI\u2010TBx\u2009=\u20095937) were included. Micro\u2010US\u2010TBx detected 2037 csPCa cases and MRI\u2010TBx 2043. The pooled DR (micro\u2010US\u2010TBx vs MRI\u2010TBx) was 1.04 (95% confidence interval 0.95\u20131.15;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200961.1%). Pooled sensitivity\/specificity were 0.88\/0.25 for micro\u2010US\u2010TBx and 0.81\/0.17 for MRI\u2010TBx. Summary receiver operating characteristic curves overlapped (area under the curve: micro\u2010US, 0.658; MRI, 0.547). Meta\u2010regression found no significant modality effect on sensitivity (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.192) or specificity (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.257). Egger's test indicated no meaningful publication bias (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.848).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The micro\u2010US\u2010TBx demonstrated csPCa detection and diagnostic accuracy comparable to MRI\u2010TBx. Given its real\u2010time imaging capability, accessibility, and potential workflow advantages, micro\u2010US\u2010TBx may represent a valuable complementary tool within contemporary PCa diagnostic pathways. Further cost\u2010effectiveness studies are warranted to better define its role in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70270","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:11:47Z","timestamp":1776341507000},"page":"196-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Micro\u2010ultrasonography\u2010 vs\n                    <scp>MRI<\/scp>\n                    \u2010targeted biopsy in prostate cancer: Updated systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-0079","authenticated-orcid":false,"given":"Jos\u00e9 Pedro Cassemiro","family":"Micheleto","sequence":"first","affiliation":[{"name":"Division of Urology, Institute of Cancer of S\u00e3o Paulo University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tallys \u00c1vila","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Urology, Institute of Cancer of S\u00e3o Paulo University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Amorim","family":"Santos","sequence":"additional","affiliation":[{"name":"Division of Urology, Institute of Cancer of S\u00e3o Paulo University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luann Porpino","family":"Sales","sequence":"additional","affiliation":[{"name":"Division of Urology, Institute of Cancer of S\u00e3o Paulo University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Iglesias","family":"Lopes","sequence":"additional","affiliation":[{"name":"Division of Urology, Institute of Cancer of S\u00e3o Paulo University of 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