{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:55Z","timestamp":1785250975410,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To measure the sensitivity of prostate\u2010specific membrane antigen\u2010positron emission tomography\/computed tomography (PSMA\u2010PET\/CT) for detecting lymph node involvement (LNI) in patients undergoing radical prostatectomy (RP) and extended pelvic lymph node dissection (PLND) and to evaluate whether PSMA nodal status independently predicts oncological outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We identified patients with localised or locoregional prostate cancer who underwent PSMA\u2010PET\/CT followed by RP (2021\u20132024) at a high\u2010volume centre and had pathologically confirmed LNI (pN1) on PLND. We evaluated the sensitivity of PSMA\u2010PET\/CT for detecting pN1 disease. Associations between PSMA\u2010PET\/CT and biochemical recurrence (BCR), any radiographic recurrence, and distant recurrence were evaluated using Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, PSMA\u2010PET\/CT detected LNI in 24 of 79 patients with pN1 disease, a sensitivity of 30% (95% confidence interval [CI] 21\u201342%). PSMA\u2010positive nodal disease (clinical N1 [cN1]) was significantly associated with BCR (hazard ratio [HR] 2.34, 95% CI 1.26\u20134.36;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009), radiographic recurrence (HR 4.23, 95% CI 1.86\u20139.58;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and distant radiographic recurrence (HR 5.81, 95% CI 1.79\u201318.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). The 1\u2010year risk of BCR approached 90% for those with cN1 disease. Median metastatic focus size was larger in cN1 vs cN0 patients (1.1 vs 0.3\u2009cm;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Limitations include relatively short follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Due to low sensitivity, PSMA\u2010PET\/CT without evidence of nodal disease does not obviate the need for PLND. However, PSMA\u2010avid nodal disease portends a nearly inevitable short interval recurrence and radiographic progression, supporting treatment intensification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70280","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:11:07Z","timestamp":1777615867000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic and prognostic utility of\n                    <scp>PSMA<\/scp>\n                    \u2010\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    in node\u2010metastatic prostate cancer"],"prefix":"10.1111","volume":"138","author":[{"given":"Nicholas A.","family":"Pickersgill","sequence":"first","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Vertosick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean A.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Liso","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Kluckert","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguz","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-0632","authenticated-orcid":false,"given":"Behfar","family":"Ehdaie","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent P.","family":"Laudone","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Eastham","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-6503","authenticated-orcid":false,"given":"Andrew J.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim A.","family":"Touijer","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-6611","authenticated-orcid":false,"given":"Christoper D.","family":"Gaffney","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology Service) Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.3771"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001698"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4573"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30314-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.03.003"},{"key":"e_1_2_10_7_1","unstructured":"Memorial Sloan Kettering Cancer Center.MSKCC Prostate Cancer Nomogram: Post\u2010Operative.2024. 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