{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:05:14Z","timestamp":1784307914242,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide an overview of the biological mechanism and pattern of oligoprogression in renal cell carcinoma (RCC) and the most updated role of surgery in this setting, highlighting scientific gaps and informing future implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A non\u2010systematic search of PubMed\/MEDLINE was performed in August 2025 including guidelines, reviews, and original studies. Additional sources were identified through manual reference screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oligoprogression in RCC likely arises from clonal evolution dynamics, with spatially confined subclone mutations and microenvironmental niches yielding differential responses to treatment. Complete metastasectomy may offer a survival benefit, spare patients toxic side effects of systemic therapy, and offers the possibility of histopathological and molecular characterisation of residual disease. Surgery is also particularly important in delayed cytoreductive nephrectomy as the site of oligoprogression. However, this must be weighed against non\u2010negligible surgical morbidity and complication rates. International guidelines recognise the role of surgical resection in the metastatic setting but emphasise low evidence levels and careful patient selection requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Limited evidence derived from the oligometastatic context constrains optimal patient selection and timing strategies in oligoprogressive RCC. Following the establishment of consensus over definitions and research gaps, future research integrating molecular biomarkers, novel imaging tracers, and multicentre collaborative studies will be essential to develop evidence\u2010based surgical management protocols for this increasingly common clinical scenario.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70281","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:59:34Z","timestamp":1776074374000},"page":"219-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oligoprogressive renal cell carcinoma: What is the role of surgery?"],"prefix":"10.1111","volume":"138","author":[{"given":"Chiara","family":"Re","sequence":"first","affiliation":[{"name":"Department of Surgery University of Cambridge, Cambridge Biomedical Centre  Cambridge UK"},{"name":"CRUK Cambridge Centre University of Cambridge  Cambridge UK"},{"name":"IRCCS San Raffaele Scientific Institute, Division of Experimental Oncology\/Unit of Urology Urological Research Institute (URI)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.J.","family":"Ince","sequence":"additional","affiliation":[{"name":"CRUK Cambridge Centre University of Cambridge  Cambridge UK"},{"name":"Department of Oncology Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Bickley","sequence":"additional","affiliation":[{"name":"Department of Medicine Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Blackmur","sequence":"additional","affiliation":[{"name":"Department of Urology Western General Hospital  Edinburgh UK"},{"name":"Institute of Genetics and Cancer, Western General Hospital University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhamad H.","family":"Ismail","sequence":"additional","affiliation":[{"name":"CRUK Cambridge Centre University of Cambridge  Cambridge UK"},{"name":"Department of Oncology Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justicia","family":"Kyeremeh","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Cambridge, Cambridge Biomedical Centre  Cambridge UK"},{"name":"CRUK Cambridge Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-4878","authenticated-orcid":false,"given":"Teele","family":"Kuusk","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Cambridge, Cambridge Biomedical Centre  Cambridge UK"},{"name":"CRUK Cambridge Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Mendes","family":"Serrao","sequence":"additional","affiliation":[{"name":"Department of Radiology Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Jones","sequence":"additional","affiliation":[{"name":"CRUK Cambridge Centre University of Cambridge  Cambridge UK"},{"name":"Department of Oncology Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-9140","authenticated-orcid":false,"given":"Grant D.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Cambridge, Cambridge Biomedical Centre  Cambridge UK"},{"name":"CRUK Cambridge Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"U.S. Food & Drug Administration.FDA Approval letter for use of sorafenib in advanced renal cancer."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030793"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30718-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.7266"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00793-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000001254"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.08.028"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.87"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-1120"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.1.8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyp167"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113205"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.057"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188759"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.10.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.10.011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58436-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176230"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134564"},{"key":"e_1_2_9_23_1","article-title":"European Association of Urology guidelines on renal cell carcinoma: the 2025 update","volume":"25","author":"Bex A","year":"2025","journal-title":"Eur Urol"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001911"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.05.537"},{"key":"e_1_2_9_26_1","unstructured":"MotzerRJ JonaschE AgarwalNet\u00a0al.NCCN Guidelines Insights: Kidney Cancer Version 3.2025.2025"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2017.06.060"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.6_suppl.642"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.07.079"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25836"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000488"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.005"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13604"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2022.11.003"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312695"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","unstructured":"LarkinJ PowlesT FrangouEet\u00a0al.First results from RAMPART: An international phase III randomised\u2010controlled trial of adjuvant durvalumab monotherapy or combined with tremelimumab for resected primary renal cell carcinoma (RCC).2025; Available at:https:\/\/cslide.ctimeetingtech.com\/esmo2025\/attendee\/confcal\/show\/session\/106","DOI":"10.1016\/j.annonc.2025.09.110"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-10926-x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.11.004"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.5_suppl.502"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.06.002"},{"key":"e_1_2_9_41_1","article-title":"Radiation fosters dose\u2010dependent and chemotherapy\u2010induced immunogenic cell death","volume":"3","author":"Golden EB","year":"2014","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.019"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23470"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00007-8"},{"key":"e_1_2_9_45_1","first-page":"671","article-title":"Nivolumab after stereotactic body radiotherapy in pretreated patients with metastatic renal cell carcinoma: the multicenter phase II NIVES study","volume":"5","author":"Franceschelli D","year":"2022","journal-title":"Eur Urol Oncol"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2025.2464929"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00345-6"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2024.2389769"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.04.028"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.03.006"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2018.1556819"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2024.10.019"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01059-5"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00440-0"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.10.015"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.5_suppl.594"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-0921"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267417"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000004588"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00723-8"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00380-8"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.70281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:29:17Z","timestamp":1784305757000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.70281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/bju.70281"],"URL":"https:\/\/doi.org\/10.1111\/bju.70281","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}