{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:44:49Z","timestamp":1792597489926,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400896"],"award-info":[{"award-number":["82400896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of flexible ureteroscopy (f\u2010URS) with a flexible and navigable suction ureteral access sheath (FANS) compared with mini\u2010percutaneous nephrolithotomy (mPCNL) in the treatment of 2\u20133\u2009cm upper urinary tract stones (UUTS), with a prespecified subgroup analysis for stones \u22652 to &lt;2.5\u2009cm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized controlled trial enrolled 326 patients with 2\u20133\u2009cm UUTS between June 2023 and December 2025. Patients were randomly assigned in a 1:1 ratio to undergo either f\u2010URS with FANS or mPCNL. A prespecified subgroup analysis was conducted for stones measuring \u22652 to &lt;2.5\u2009cm. The primary outcomes were the immediate and 1\u2010month stone\u2010free rate (SFR). Secondary outcomes included the operative duration, decrease in haemoglobin, hospital stay, and complication rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The baseline characteristics were comparable between the two groups. In the overall 2\u20133\u2009cm cohort, the FANS group achieved immediate and 1\u2010month SFRs comparable to those of the mPCNL group. Although the operative time was longer in the FANS group, it was associated with significantly less haemoglobin loss and a shorter hospital stay, with no significant difference in infection\u2010related complications. Notably, in the subgroup of stones \u22652 to &lt;2.5\u2009cm, the FANS group demonstrated a non\u2010inferior SFR at both time points, and the operative time was not significantly longer than that of the mPCNL group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For 2\u20133\u2009cm UUTS, f\u2010URS with FANS offers a SFR comparable to that of mPCNL, along with the advantages of reduced blood loss and shorter hospitalization. In the \u22652 to &lt;2.5\u2009cm subgroup, FANS shows comprehensive benefits over mPCNL. These findings support FANS as an effective alternative to mPCNL for 2\u20133\u2009cm stones and a potentially preferred option for stones measuring 2\u20132.5\u2009cm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70367","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:19:37Z","timestamp":1782904777000},"page":"687-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["F\u2010\n                    <scp>URS<\/scp>\n                    with\n                    <scp>FANS<\/scp>\n                    versus\n                    <scp>mPCNL<\/scp>\n                    for 2\u20133\u2009cm\n                    <scp>UUTS<\/scp>\n                    : a\n                    <scp>RCT<\/scp>\n                    with a subgroup analysis of 2\u20132.5\u2009cm stones"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-491X","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2873-2746","authenticated-orcid":false,"given":"Junkai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-916X","authenticated-orcid":false,"given":"Linguo","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1115-8283","authenticated-orcid":false,"given":"Liwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3716","authenticated-orcid":false,"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Tianjin Institute of Urology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.03.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13041114"},{"key":"e_1_2_11_4_1","first-page":"653","article-title":"International Alliance of urolithiasis (IAU) guideline on percutaneous nephrolithotomy","volume":"74","author":"Zeng G","year":"2022","journal-title":"Minerva Urol Nephrol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04107-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-022-01349-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-023-01459-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2020.0860"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-025-04707-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2021.01.010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03210-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2024.05.010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102724"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-025-01781-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2022.0004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04075-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-024-01539-6"},{"key":"e_1_2_11_18_1","first-page":"225","article-title":"Comparison of the efficacy of Ureteroscopy through a flexible vacuum\u2010assisted ureteral access sheath with tubeless\u2010mini percutaneous Nephrolithotomy for the treatment of 3\u20102 cm renal calculi","volume":"22","author":"Deng G","year":"2025","journal-title":"Urol J"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.06.001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04697-1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04648-w"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-023-01462-2"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.0533"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000576"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000394"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.70367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:27:49Z","timestamp":1788845269000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.70367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/bju.70367"],"URL":"https:\/\/doi.org\/10.1111\/bju.70367","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}