{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:07:16Z","timestamp":1788847636239,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To prove the oncological benefit of ablative radiotherapy in patients with up to five metastases from castration\u2010resistant prostate cancer (CRPC) a single\u2010centre randomised trial was initiated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This monocentric, randomised, phase II clinical trial enrolled patients with up to five prostate\u2010specific membrane antigen\u2010positive bone or lymph node metastases developing prostate\u2010specific antigen (PSA) progression during androgen deprivation (ADT) or ADT and androgen\u2010receptor targeted therapy. Participants were randomised (2:1) to receive metastasis\u2010directed therapy (MDT) or observation (OBS) without changing systemic therapy. The primary endpoint was the proportion of patients having PSA progression within 1\u2009year, with statistical analyses conducted using intention\u2010to\u2010treat principles. Here, results of a planned interim analysis of the primary endpoint are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 30 patients (12 in the observation arm and 18 in the MDT arm) were enrolled, PSA progression within 1\u2009year occurred in 44% of the MDT group vs 75% in the OBS group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.14, not significant). The median time to PSA progression was significantly longer in the MDT arm (12.4\u2009months) compared to the OBS arm (2.9\u2009months,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). The pre\u2010defined criteria to discontinue the study were not met. Limitations include the single\u2010centre design and small sample size at interim analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This pre\u2010planned interim analysis of the primary endpoint did not meet the discontinuation criteria of the study protocol, suggesting that MDT in oligometastatic CRPC may extend the time to PSA progression without immediate change of systemic therapy. The continuation of the study in a multicentre setting is planned (Institutional funding by the TU Dresden,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT04141709).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70368","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:34:25Z","timestamp":1782984865000},"page":"659-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ablative radiotherapy in castration\u2010resistant prostate cancer"],"prefix":"10.1111","volume":"138","author":[{"given":"Tobias","family":"H\u00f6lscher","sequence":"first","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"OncoRay \u2013 National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, Helmholtz\u2010Zentrum Dresden\u2010Rossendorf  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Lohaus","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"OncoRay \u2013 National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, Helmholtz\u2010Zentrum Dresden\u2010Rossendorf  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Koi","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"OncoRay \u2013 National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, Helmholtz\u2010Zentrum Dresden\u2010Rossendorf  Dresden Germany"},{"name":"Helmholtz\u2010Zentrum Dresden\u2010Rossendorf Institute of Radiooncology \u2010 OncoRay  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kotzerke","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Hober\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Borkowetz","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"L\u00f6ck","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"OncoRay \u2013 National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, Helmholtz\u2010Zentrum Dresden\u2010Rossendorf  Dresden Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mechthild","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, A Partnership Between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"OncoRay \u2013 National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, Helmholtz\u2010Zentrum Dresden\u2010Rossendorf  Dresden Germany"},{"name":"Helmholtz\u2010Zentrum Dresden\u2010Rossendorf Institute of Radiooncology \u2010 OncoRay  Dresden Germany"},{"name":"German Cancer Consortium (DKTK), 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