{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:49:14Z","timestamp":1793677754839,"version":"4.5.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To prospectively evaluate the influence of multiparametric magnetic resonance imaging (mpMRI) quality, as assessed by the Prostate Imaging Quality (PI\u2010QUAL) score, on diagnostic accuracy in men undergoing prostate biopsy after external mpMRI at a tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>From June 2024 to July 2025, a total of 246 consecutive patients referred for prostate biopsy after external mpMRI were prospectively enrolled. All patients underwent systematic biopsy with targeted biopsy when indicated. External mpMRI scans were centrally reviewed by expert uro\u2010radiologists blinded to clinical and pathological data. Image quality and lesion grading were reassessed using PI\u2010QUAL v2 and Prostate Imaging Reporting and Data System (PI\u2010RADS) v2.1. Accuracy for clinically significant prostate cancer (csPCa; International Society of Urological Pathology [ISUP] grade \u22652) was assessed using receiver operating characteristic\u2013derived area under the curve AUC before and after review, stratified by PI\u2010QUAL (1\u20132 vs 3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age and prostate\u2010specific antigen (PSA) were 66.5\u2009years (interquartile range [IQR] 61\u201373) and 6.6\u2009ng\/mL (IQR 4.8\u20139.7), respectively, and csPCa was detected in 128 patients (52%). After review, 49 (20%), 113 (46%), and 84 (34%) mpMRI scans were classified as PI\u2010QUAL 1, 2, and 3, respectively. The proportion of indeterminate PI\u2010RADS 3 findings was 27% for PI\u2010QUAL 1, 15% for PI\u2010QUAL 2, and 8% for PI\u2010QUAL 3. PI\u2010QUAL 3 scans demonstrated greater diagnostic accuracy than PI\u2010QUAL 1\u20132 (AUC 0.79 vs 0.66,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). Central review improved csPCa detection in both PI\u2010QUAL 1\u20132 (AUC 0.63 vs 0.78,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and PI\u2010QUAL 3 (AUC 0.77 vs 0.89,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) scans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High\u2010quality mpMRI achieved approximately 15% higher diagnostic accuracy for csPCa and were associated with a lower prevalence of indeterminate findings than were low\u2010quality MRI scans; centralized expert review reclassified nearly half of PI\u2010RADS assessments. These findings support upfront high\u2010quality mpMRI acquisition and PI\u2010QUAL\u2013based quality control to optimize diagnosis and reduce unnecessary procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70373","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:42:22Z","timestamp":1783503742000},"page":"714-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of prostate\n                    <scp>mpMRI<\/scp>\n                    quality on diagnostic accuracy in prostate cancer: a prospective study"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4612-2440","authenticated-orcid":false,"given":"Donato","family":"Cannoletta","sequence":"first","affiliation":[{"name":"Unit of Urology\/Division of Oncology, Gianfranco Soldera Prostate Cancer Laboratory, Urological Research Institute IRCCS San Raffaele 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