{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:45:46Z","timestamp":1791776746962,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To provide a comprehensive analysis regarding outcomes of repeated screening and detection of low\u2010grade versus high\u2010grade cancer from the European Randomised Study of Screening for Prostate Cancer (ERSPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study analysed men aged 55\u201369\u2009years at random across the ERSPC trial centres except France. Men in the screening arm were classified as ever\u2010attenders (who attended at least one screening cycle) or non\u2010attenders (who did not attend a specific screening cycle). Cancer detection rates (CDRs) were calculated by age group and centre across three screening cycles. A secondary analysis incorporated interval prostate cancer (PCa) cases\u2014those diagnosed outside the screening protocol\u2014among both ever\u2010attenders and non\u2010attenders. Incidence data from the control arm were included for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on screen\u2010detected cases, CDRs were consistently higher for low\u2010grade than for intermediate\u2010 and high\u2010grade cases across all centres and screening cycles. Trends in CDRs for high\u2010grade cases varied by centre: CDRs decreased from the first to the second cycle and increased again during the third cycle in most centres, whereas CDRs increased in Spain with each successive screening cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ERSPC data show a decreasing detection rate for low\u2010grade cancer and substantial variation in the detection rate for intermediate\u2010 and high\u2010grade cancer between centres across repeated screening rounds. Increasing interval and non\u2010attender cancers indicate diminishing effectiveness of uniform screening schedules. These findings support personalised screening approaches and improved strategies to maintain participation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70380","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:38:58Z","timestamp":1783154338000},"page":"822-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer detection in the European Randomised Study of Screening for Prostate Cancer (\n                    <scp>ERSPC<\/scp>\n                    )"],"prefix":"10.1111","volume":"138","author":[{"given":"Niko","family":"Pasanen","sequence":"first","affiliation":[{"name":"Faculty of Social Sciences Tampere University  Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Talala","sequence":"additional","affiliation":[{"name":"Cancer Society of Finland  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Remmers","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus MC Cancer Institute, Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teuvo L. J.","family":"Tammela","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Department of Urology Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Hugosson","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Urology, Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecka Arnsrud","family":"Godtman","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Urology, Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital  Gothenburg 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