{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:07:17Z","timestamp":1788847637741,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007568","name":"Urology Foundation","doi-asserted-by":"publisher","award":["WSSY.NEP032"],"award-info":[{"award-number":["WSSY.NEP032"]}],"id":[{"id":"10.13039\/501100007568","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate\n                      <jats:italic>ex vivo<\/jats:italic>\n                      fluorescence confocal microscopy (FCM) for immediate detrusor muscle (DM) assessment during primary transurethral resection of bladder tumour (TURBT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, blinded, paired\u2010cohort feasibility study enrolled consecutive patients undergoing primary TURBT for suspected non\u2010muscle\u2010invasive bladder cancer between September 2024 and September 2025 (IB1\u2010LaserComplete study; International Standard Randomised Controlled Trial Number Register [ISRCTN]16114765).\n                      <jats:italic>Ex vivo<\/jats:italic>\n                      FCM generates immediate high\u2010resolution digital images of fresh tissue, enabling immediate DM assessment. Intraoperative\n                      <jats:italic>ex vivo<\/jats:italic>\n                      FCM imaging of\n                      <jats:italic>en face<\/jats:italic>\n                      tumour base specimens was performed using the Histolog\u00ae scanner (SamanTree Medical SA, Lausanne, Switzerland). DM status was reported by a blinded uro\u2010pathologist and urologist. Formalin\u2010fixed histopathology served as the reference standard. The primary outcome was technical feasibility, defined as acquisition of an interpretable FCM image. Secondary outcomes included exploratory diagnostic performance, inter\u2010observer agreement and time to confirmation of DM status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 34 patients were recruited and 30 had evaluable paired specimens. DM was absent in 13% (four of 30). FCM was sufficient for determining DM status in all patients (100%; 30 of 30). Sensitivity, specificity, positive predictive value, negative predictive value (NPV) were 42% (95% confidence interval [CI] 26\u201361%), 100% (95% CI 51\u2013100%), 100% (95% CI 74\u2013100%), and 21% (95% CI 9\u201343%), respectively. Inter\u2010observer agreement between the uro\u2010pathologist and urologist was high at 83% (\u03ba\u2009=\u20090.72, 95% CI 0.47\u20130.97). The median (interquartile range) time to confirm DM status was 5.4\u2009(4.95\u20135.39)\u2009min vs 11\u2009(7\u201313.8)\u2009days using standard histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fluorescence confocal microscopy is feasible for rapid intraoperative imaging of TURBT specimens and demonstrates excellent specificity for detection of DM. However, its low sensitivity and NPV preclude use as a stand\u2010alone tool to exclude DM intraoperatively. Based on these findings, FCM should not guide intraoperative decision making outside research settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70395","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:22:17Z","timestamp":1786681337000},"page":"705-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immediate intraoperative detrusor muscle status at primary transurethral resection of bladder tumour: a\u00a0prospective, blinded, paired cohort, feasibility study\u00a0using fluorescence confocal microscopy (\n                    <scp>IB1<\/scp>\n                    \u2010\n                    <scp>LaserComplete<\/scp>\n                    study)"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-7508","authenticated-orcid":false,"given":"Martin 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