{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:28:31Z","timestamp":1793788111382,"version":"4.6.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prostate cancer (PCa) is the second most common cancer in men. For patients with high\u2010volume metastatic PCa (mPCa) who are fit for docetaxel, a triplet therapy regimen consisting of androgen deprivation therapy (ADT), chemotherapy, and an androgen receptor pathway inhibitor (ARPI) is recommended. Adding local radiotherapy to triplet therapy has been shown to alleviate symptoms and reduce disease progression. However, the benefit of combining triplet therapy with local surgery remains unclear and warrants further investigation in the present study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This is an open\u2010label, prospective, two\u2010arm, multicentre, randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Endpoints<\/jats:title>\n                    <jats:p>Primary endpoints are progression\u2010free survival (PFS) and the 1\u2010year PFS rate. Disease progression is defined as prostate\u2010specific antigen (PSA) progression, radiological progression, or unequivocal clinical progression. Secondary endpoints include overall survival (OS) and health\u2010related quality of life (HRQoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients aged 18\u201375\u2009years with high\u2010volume mPCa will receive ADT (triptorelin 15\u2009mg every 3\u2009months), four\u2013six\u2009cycles of chemotherapy (docetaxel 75\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      every 3\u2009weeks), and an ARPI (rezvilutamide 240\u2009mg once daily). Patients achieving a PSA level \u22640.2\u2009ng\/mL and deemed suitable candidates for surgery will be enrolled. A total of 88 eligible patients will be randomised in a 1:1 ratio. The control group will continue treatment with triptorelin and rezvilutamide, while the experimental group will receive robot\u2010assisted cytoreductive prostatectomy in addition to triptorelin and rezvilutamide. Baseline PSA levels will be recorded and re\u2010examined at each chemotherapy cycle and every 3\u2009months thereafter. Radiological evaluations will be performed every 6\u2009months. Clinical progression will be assessed based on pain severity, performance status, and the need to initiate new anticancer therapy. HRQoL will be evaluated every 3\u2009months. PFS and OS will be estimated using Kaplan\u2013Meier curves and compared with the log\u2010rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR2600121819<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70421","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:02:41Z","timestamp":1786705361000},"page":"807-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of triplet therapy combined with robot\u2010assisted cytoreductive prostatectomy for high\u2010volume metastatic prostate cancer: a multicentre randomised controlled trial protocol"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-9596","authenticated-orcid":false,"given":"Xiangwei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center The Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuobin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Urology Dalang Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Changan Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqi","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center The Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8804-1867","authenticated-orcid":false,"given":"Binyuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center The Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linze","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Dalang Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Changan Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0024-9415","authenticated-orcid":false,"given":"Jun","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center The Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.0228"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2015.01.022"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.07.020"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.1970"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04448-6"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-026-01594-4"},{"key":"e_1_2_13_9_1","volume-title":"Prostate cancer. 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