{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:18:51Z","timestamp":1787746731724,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008719","name":"Movember Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our objective was to evaluate patient\u2010reported sexual function (SF) outcomes and sexual aid use 12\u2009months after curative treatment for prostate cancer (PC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients &amp; Methods<\/jats:title>\n                    <jats:p>This prospective registry\u2010based cohort study analysed men with localized or locally advanced PC enrolled in the TrueNTH Global Registry. Patients with baseline and 12\u2010month patient\u2010reported outcome measures after radical prostatectomy (RP), external beam radiotherapy (EBRT)\u2009\u00b1\u2009androgen\u2010deprivation therapy (ADT), or brachytherapy (BT) were included. SF was assessed using the EPIC\u201026 sexual function domain score (SFDS). Baseline and 12\u2010month EPIC\u201026 SFDS were compared by treatment group, with additional analyses among RP patients examining outcomes by intent to nerve spare and sexual aid use. Linear regression, adjusted for age, National Comprehensive Cancer Network risk group, baseline SFDS, and intent to nerve spare was used to identify predictors of 12\u2010month SFDS among surgery patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 13 413 men were analysed (RP 85.2%, EBRT only 9.1%, EBRT+ADT 4.3%, BT 1.3%). SF declined significantly across all modalities. Median SFDS reduction was greatest after RP (\u221260.0%) and smallest after BT (\u221240.2%). At 12\u2009months, poor or absent erectile function was reported by 63.6\u201391.8% of patients, highest after RP and EBRT+ADT. Sexual aid use increased after treatment but remained low overall. Given the retrospective design and non\u2010representative sites in an international registry setting, these findings should be interpreted as associational rather than causal because of the potential for unmeasured confounding and cross\u2010country heterogeneity in treatment selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>All curative PC treatments were associated with substantial deterioration in SF. These findings support enhanced pre\u2010treatment counselling and early integration of proactive management and structured sexual rehabilitation into survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70431","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:24:41Z","timestamp":1787743481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sexual function after prostate cancer surgery or radiotherapy in an international registry"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-5404","authenticated-orcid":false,"given":"Y.","family":"Hess\u2010Busch","sequence":"first","affiliation":[{"name":"Department for Oncology Kliniken Essen\u2010Mitte  Essen Germany"},{"name":"Department of Urology University Hospital Frankfurt, Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-8398","authenticated-orcid":false,"given":"C.","family":"Darr","sequence":"additional","affiliation":[{"name":"Department for Urology University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"P\u00fcllen","sequence":"additional","affiliation":[{"name":"Department for Urology University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7213-9417","authenticated-orcid":false,"given":"M.","family":"Al\u2010Nader","sequence":"additional","affiliation":[{"name":"Department for Urology University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wahl","sequence":"additional","affiliation":[{"name":"Department for Urology University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1663-370X","authenticated-orcid":false,"given":"A. V.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Departments of Urology, OBGYN, &amp; Surgery University of California, Los Angeles (UCLA)  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wilhalme","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core, David Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9387-5031","authenticated-orcid":false,"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core, David Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hadaschik","sequence":"additional","affiliation":[{"name":"Department for Urology University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9902-5368","authenticated-orcid":false,"given":"J.","family":"Hess","sequence":"additional","affiliation":[{"name":"Department for Urology University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TrueNTH Global Registry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_2_11_3_1","volume-title":"World Cancer Report: Cancer Research for Cancer Prevention","author":"Soerjomataram 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