{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:50:27Z","timestamp":1790844627653,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["17\/150\/01"],"award-info":[{"award-number":["17\/150\/01"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"abstract":"\n Objectives<\/jats:title>\n Primary objective: to determine whether prostate gland partial ablation (PA) has non\u2010inferior oncological treatment success vs radical treatment (RT) of localised intermediate\u2010risk prostate cancer (irPCa). Secondary objectives: to compare (i) participant\u2010reported urinary and sexual dysfunction side effects, (ii) short\/medium term serious adverse events, (iii) health\u2010related quality of life (HRQoL), (iv) cost\u2010effectiveness; and to report (v) the need for repeat PA, (vi) accuracy of magnetic resonance imaging and biopsy protocols in determining suitability for PA, (vii) disease progression, local spread and metastases, (viii) medium\u2010term disease\u2010specific and overall mortality.<\/jats:p>\n <\/jats:sec>\n \n Participants and Methods<\/jats:title>\n The \u2018Partial prostate Ablation versus Radical Treatment\u2019 (PART; International Standard Randomised Controlled Trial Number ISRCTN17249875) is a UK\u2010wide, multicentre, pragmatic, randomised controlled trial investigating whether PA (high\u2010intensity focused ultrasound [HIFU] or irreversible electroporation [IRE]) is non\u2010inferior to RT (radical prostatectomy, radical radiotherapy, or low\u2010dose\u2010rate brachytherapy [LDR\u2010B]) in treating localised irPCa. A Qualitative Research Integrated within Trials (QuinteT) Recruitment Intervention is included to optimise recruitment and informed consent. Primary outcome treatment success for PA will be determined by prostate biopsies and imaging, and for RT using standard definitions. Participants will receive treatment according to their randomised allocation, with HIFU or IRE for PA depending on lesion location, and radical prostatectomy, radical radiotherapy, or LDR\u2010B according to patient and physician preference for RT. Based on 95% and 85% oncological treatment success for RT and PA, respectively, with a non\u2010inferiority margin of 20%, at median 3\u2009years of follow\u2010up, PART requires 275 recruited men (137 per group, randomised on a 1:1 basis), for 80% power, with a one\u2010sided alpha of 0.025. Allowing for a 10% total withdrawal or dropout rate, PART requires 306 recruited and randomised participants.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The PART trial will provide robust prospective data and high\u2010level randomised evidence to determine oncological treatment effectiveness of PA vs RT for localised irPCa, along with comparative side effect, HRQoL, and health economics evaluations, to inform clinical decision\u2010making.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.70448","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:50:16Z","timestamp":1789779016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The\n PART<\/scp>\n randomised trial protocol: Partial Ablation versus Radical Treatment for prostate cancer"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-9251","authenticated-orcid":false,"given":"Richard J.","family":"Bryant","sequence":"first","affiliation":[{"name":"Department of Urology, Churchill Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"},{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Surgical Intervention Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-1840","authenticated-orcid":false,"given":"Tom","family":"Leslie","sequence":"additional","affiliation":[{"name":"Department of Urology, Churchill Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"},{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-4478","authenticated-orcid":false,"given":"Marc","family":"Laniado","sequence":"additional","affiliation":[{"name":"Department of Urology, Wexham Park Hospital Frimley Health NHS Foundation Trust Slough UK"},{"name":"Harold Hopkins Department of Urology, Royal Berkshire Hospital Royal Berkshire NHS Foundation Trust Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3396-5937","authenticated-orcid":false,"given":"Abhishek","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Urology NHS Lothian, Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Grey","sequence":"additional","affiliation":[{"name":"Department of Urology University College London Hospitals NHS Foundation Trust London UK"},{"name":"Department of Urology, The Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-8013","authenticated-orcid":false,"given":"John","family":"Withington","sequence":"additional","affiliation":[{"name":"Department of Urology University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Blick","sequence":"additional","affiliation":[{"name":"Harold Hopkins Department of Urology, Royal Berkshire Hospital Royal Berkshire NHS Foundation Trust Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Streeter","sequence":"additional","affiliation":[{"name":"Department of Urology East Kent Hospitals University NHS Foundation Trust, Kent and Canterbury Hospital Canterbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kotwal","sequence":"additional","affiliation":[{"name":"Department of Urology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9547-9353","authenticated-orcid":false,"given":"Oliver","family":"Hulson","sequence":"additional","affiliation":[{"name":"Department of Urology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Urology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Urology NHS Lothian, Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altan","family":"Omer","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospitals Coventry and Warwickshire NHS Trust, University Hospital Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-1208","authenticated-orcid":false,"given":"Taimur T.","family":"Shah","sequence":"additional","affiliation":[{"name":"Imperial Prostate, Division of Surgery, Department of Surgery and Cancer Imperial College London London UK"},{"name":"Imperial Urology, Charing Cross Hospital Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7434-5719","authenticated-orcid":false,"given":"Nishant","family":"Bedi","sequence":"additional","affiliation":[{"name":"Department of Urology, Wexham Park Hospital Frimley Health NHS Foundation Trust Slough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Stroman","sequence":"additional","affiliation":[{"name":"Harold Hopkins Department of Urology, Royal Berkshire Hospital Royal Berkshire NHS Foundation Trust Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0202-7912","authenticated-orcid":false,"given":"Caroline","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Urology University College London Hospitals NHS Foundation Trust London UK"},{"name":"Division of Surgery and Interventional Science University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Sooriakumaran","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Department of Urology University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-6723","authenticated-orcid":false,"given":"Hashim U.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Imperial Prostate, Division of Surgery, Department of Surgery and Cancer Imperial College London London UK"},{"name":"Imperial Urology, Charing Cross Hospital Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon F.","family":"Brewster","sequence":"additional","affiliation":[{"name":"Department of Urology, Churchill Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-3666","authenticated-orcid":false,"given":"Vicki S.","family":"Barber","sequence":"additional","affiliation":[{"name":"Oxford Clinical Trials Research Unit (OCTRU), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-1486","authenticated-orcid":false,"given":"Aimi","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Surgical Intervention Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-0733","authenticated-orcid":false,"given":"Clare","family":"Calvert","sequence":"additional","affiliation":[{"name":"Oxford Clinical Trials Research Unit (OCTRU), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Scaife","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Surgical Intervention Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Patient and Public Involvement Representative, PART Trial Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-2195","authenticated-orcid":false,"given":"Filipa","family":"Landeiro","sequence":"additional","affiliation":[{"name":"Health Economics Research Centre, Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-1850","authenticated-orcid":false,"given":"Jane","family":"Wolstenholme","sequence":"additional","affiliation":[{"name":"Health Economics Research Centre, Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Department of Oncology, Churchill Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Verrill","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Department of Cellular Pathology Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelagh","family":"Lovell","sequence":"additional","affiliation":[{"name":"Department of Urology, Churchill Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"},{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pirkl","sequence":"additional","affiliation":[{"name":"Department of Urology, Churchill Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"},{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus","family":"Gleeson","sequence":"additional","affiliation":[{"name":"Department of Radiology Oxford University Hospitals NHS Foundation Trust, Churchill Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne","family":"Williams","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Surgical Intervention Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-5030","authenticated-orcid":false,"given":"Jo","family":"Cook","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Surgical Intervention Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-1916","authenticated-orcid":false,"given":"Catherine R.","family":"Holt","sequence":"additional","affiliation":[{"name":"Population Health Sciences University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Hill","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Surgical Intervention Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4156-6989","authenticated-orcid":false,"given":"Jonathan","family":"Cook","sequence":"additional","affiliation":[{"name":"Oxford Clinical Trials Research Unit (OCTRU), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Radford","sequence":"additional","affiliation":[{"name":"Oxford Clinical Trials Research Unit (OCTRU), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-8112","authenticated-orcid":false,"given":"Ioana R.","family":"Marian","sequence":"additional","affiliation":[{"name":"Oxford Clinical Trials Research Unit (OCTRU), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Macpherson","sequence":"additional","affiliation":[{"name":"Department of Radiology Oxford University Hospitals NHS Foundation Trust, Churchill Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-9549","authenticated-orcid":false,"given":"Daisy","family":"Elliott","sequence":"additional","affiliation":[{"name":"Population Health Sciences University of Bristol Bristol UK"},{"name":"NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny L.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Population Health Sciences University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddie C.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Department of Urology, Churchill Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"},{"name":"Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Surgical Intervention Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU\u2010EANM\u2010ESTRO\u2010ESUR\u2010ISUP\u2010SIOG guidelines on prostate Cancer\u20102024 update. Part I: screening, diagnosis, and local treatment with curative intent","volume":"86","author":"Cornford P","year":"2024","journal-title":"Eur Urol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2214122","article-title":"Fifteen\u2010year outcomes after monitoring, surgery, or radiotherapy for prostate cancer","volume":"388","author":"Hamdy FC","year":"2023","journal-title":"N Engl J Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1056\/NEJMcibr0905562","article-title":"The index lesion and the origin of prostate cancer","volume":"361","author":"Ahmed HU","year":"2009","journal-title":"N Engl J Med"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.21037\/tau.2019.09.12","article-title":"Targeting the cancer lesion, not the whole prostate","volume":"9","author":"Bedi N","year":"2020","journal-title":"Transl Androl Urol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41391-020-0206-6","article-title":"Focal therapy for localized prostate cancer in the era of routine multi\u2010parametric MRI","volume":"23","author":"Connor MJ","year":"2020","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prnil.2025.07.002","article-title":"Advances in focal therapy for prostate cancer: current modalities, outcomes, and future directions","volume":"14","author":"Roldan\u2010Testillano R","year":"2026","journal-title":"Prostate Int"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.eururo.2022.01.005","article-title":"Cancer control outcomes following focal therapy using high\u2010intensity focused ultrasound in 1379 men with nonmetastatic prostate cancer: a multi\u2010institute 15\u2010year experience","volume":"81","author":"Reddy D","year":"2022","journal-title":"Eur Urol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ucl.2025.09.010","article-title":"Focal therapies for localized prostate cancer","volume":"53","author":"Noun J","year":"2026","journal-title":"Urol Clin North Am"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/bju.16122","article-title":"Prostate cancer outcomes following whole\u2010gland and focal high\u2010intensity focused ultrasound","volume":"132","author":"Parry MG","year":"2023","journal-title":"BJU Int"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.prnil.2025.08.002","article-title":"Irreversible electroporation for partial gland ablation: clinical application and outcomes","volume":"14","author":"Liu J","year":"2026","journal-title":"Prostate Int"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41391-025-00956-x","article-title":"New kids on the block: MRI guided transrectal focused US, TULSA, focal laser ablation, histotripsy \u2013 a comprehensive review","volume":"29","author":"Ghai S","year":"2026","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.eururo.2024.11.006","article-title":"Whole\u2010gland or subtotal high\u2010intensity focused ultrasound versus radical prostatectomy: the prospective, noninferiority, nonrandomized HIFI trial","volume":"87","author":"Ploussard G","year":"2025","journal-title":"Eur Urol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.eururo.2025.06.003","article-title":"Irreversible electroporation for prostate tissue ablation in patients with intermediate\u2010risk prostate cancer: results from the PRESERVE trial","volume":"89","author":"George AK","year":"2026","journal-title":"Eur Urol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi\u2010parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study","volume":"389","author":"Ahmed HU","year":"2017","journal-title":"Lancet"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI\u2010targeted or standard biopsy for prostate\u2010cancer diagnosis","volume":"378","author":"Kasivisvanathan V","year":"2018","journal-title":"N Engl J Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.6004\/jnccn.2026.0023","article-title":"NCCN guidelines\u00ae insights: prostate cancer, version 5.2026","volume":"24","author":"Spratt DE","year":"2026","journal-title":"J Natl Compr Cancer Netw"},{"key":"e_1_2_9_18_1","unstructured":"National Institute for Health and Care Excellence.Focal therapy using high\u2010intensity focused ultrasound for localised prostate cancer. HealthTech guidance reference number: HTG667.2023. Available at:https:\/\/www.nice.org.uk\/guidance\/HTG667\/chapter\/1\u2010Recommendations"},{"key":"e_1_2_9_19_1","unstructured":"EAU \u2010 EANM \u2010 ESTRO \u2010 ESUR \u2010 ISUP \u2013 SIOG Guidelines on Prostate Cancer 2026. Available at:https:\/\/uroweb.org\/guidelines\/prostate\u2010cancer\/chapter\/treatment. Accessed 17 April 2026"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta22520","article-title":"Partial ablation versus radical prostatectomy in intermediate\u2010risk prostate cancer: the PART feasibility RCT","volume":"22","author":"Hamdy FC","year":"2018","journal-title":"Health Technol Assess"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/bju.14432","article-title":"Overcoming difficulties with equipoise to enable recruitment to a randomised controlled trial of partial ablation vs radical prostatectomy for unilateral localised prostate cancer","volume":"122","author":"Elliott D","year":"2018","journal-title":"BJU Int"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<873::AID-SIM779>3.0.CO;2-I","article-title":"Interval estimation for the difference between independent proportions: comparison of eleven methods","volume":"17","author":"Newcombe RG","year":"1998","journal-title":"Stat Med"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41391-020-00315-y","article-title":"Focal therapy compared to radical prostatectomy for non\u2010metastatic prostate cancer: a propensity score\u2010matched study","volume":"24","author":"Shah TT","year":"2021","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/s41391-021-00369-6","article-title":"Conventional radical versus focal treatment for localised prostate cancer: a propensity score weighted comparison of 6\u2010year tumour control","volume":"24","author":"Son MJ","year":"2021","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/JU.0000000000000754","article-title":"Evaluating the trade\u2010offs men with locasied prostate cancer make between the risks and benefits of treatments: the COMPARE study","volume":"204","author":"Watson V","year":"2020","journal-title":"J Urol"},{"key":"e_1_2_9_26_1","unstructured":"NCT03668652. Available at:https:\/\/clinicaltrials.gov\/study\/NCT03668652"},{"issue":"5","key":"e_1_2_9_27_1","article-title":"Final, three\u2010year oncological results of a randomized clinical trial (FARP) comparing focal ablation and radical prostatectomy in patients with unilateral clinically significant prostate cancer","volume":"213","author":"Baco E","year":"2025","journal-title":"J Urol"},{"key":"e_1_2_9_28_1","unstructured":"NCT05513443. Available at:https:\/\/clinicaltrials.gov\/study\/NCT05513443"},{"key":"e_1_2_9_29_1","unstructured":"NCT06223295. Available at:https:\/\/clinicaltrials.gov\/study\/NCT06223295"},{"key":"e_1_2_9_30_1","unstructured":"NCT05710861. Available at:https:\/\/clinicaltrials.gov\/study\/NCT05710861"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.70448","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:50:21Z","timestamp":1789779021000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.70448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":29,"alternative-id":["10.1111\/bju.70448"],"URL":"https:\/\/doi.org\/10.1111\/bju.70448","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bju.70448"}}