{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:45:47Z","timestamp":1791776747652,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate cancer control, renal function trajectories, and dialysis risk in patients with a solitary kidney treated with endoscopic kidney\u2010sparing surgery (eKSS) for upper tract urothelial carcinoma (UTUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective multicentre cohort study including 62 consecutive patients with UTUC and a solitary kidney treated with primary eKSS between 2006 and 2024 at two tertiary referral centres. All patients underwent ureteroscopic biopsy and laser ablation followed by intensified surveillance with mandatory second\u2010look ureteroscopy and repeat retreatment as needed. Primary endpoints were upper tract recurrence, progression, cancer\u2010specific mortality, and dialysis dependency. Competing\u2010risk cumulative incidence functions and linear mixed\u2010effects models were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 71\u2009years (interquartile range [IQR] 67\u201377), and baseline estimated glomerular filtration rate (eGFR) was 48\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      (IQR 40\u201370). High\u2010grade disease at initial ureteroscopy was present in 12 patients (19%). Over a median follow\u2010up of 65\u2009months, patients underwent a median of five ureteroscopies (IQR 3\u20139), and 16 (26%) ultimately underwent radical nephroureterectomy. The cumulative incidence of upper tract recurrence was 70% (95% confidence interval [CI] 58\u201383) at 5\u2009years. The 5\u2010year cumulative incidence of progression was 40% (95% CI 26\u201354). Cancer\u2010specific mortality was 20% (95% CI 7.9\u201332) at 5\u2009years. Dialysis dependency occurred in 32% (95% CI 18\u201345) at 5\u2009years, predominantly among patients with baseline eGFR &lt;30\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      (hazard ratio 5.68; 95% CI 1.20\u201327.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.029). Mixed\u2010effects modelling showed a mean annual eGFR decline of 2.9\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI 1.2\u20134.6).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with UTUC and a solitary kidney, eKSS delivered within an intensive surveillance programme provided durable renal preservation with acceptable oncological outcomes. Despite frequent recurrences requiring repeated ureteroscopic interventions, cancer\u2010specific mortality remained limited, supporting eKSS as a viable alternative to radical nephroureterectomy in imperative clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70454","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:24:42Z","timestamp":1789611882000},"page":"894-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic kidney\u2010sparing surgery for upper tract urothelial carcinoma in patients with a solitary kidney"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6126-9889","authenticated-orcid":false,"given":"Pietro","family":"Scilipoti","sequence":"first","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"Endolase Lab, GRC20\u2010Sorbonne University PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"},{"name":"Department of Experimental Oncology\/Unit of Urology, URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5593-5995","authenticated-orcid":false,"given":"Federico","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"Endolase Lab, GRC20\u2010Sorbonne University PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1744-8913","authenticated-orcid":false,"given":"Carlos Gonzalez","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"Endolase Lab, GRC20\u2010Sorbonne University PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris 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GRC20\u2010Sorbonne University PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1105-7338","authenticated-orcid":false,"given":"Andrea","family":"Folcia","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology\/Unit of Urology, URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1102-6381","authenticated-orcid":false,"given":"Angelo","family":"Occhi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology\/Unit of Urology, URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan 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