{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:10:11Z","timestamp":1790691011277,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the impact of prolonged time to surgery on cancer\u2010specific mortality (CSM) in patients with pathological T stage (pT)1b\u20132 N0M0 renal cell carcinoma (RCC) treated with nephrectomy (either partial [PN] or radical [RN]). Within the Surveillance, Epidemiology and End Results (SEER) database (2004\u20132021), we tested the effect of time to surgery &gt;3 vs \u22643\u2009months on CSM in patients with pT1b\u20102N0M0 RCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Propensity score matching (PSM) and multivariable competing risks regression (CRR) were performed. Subgroup analyses stratified patients according to time to surgery interval (\u22641 vs 1\u20133\u2009months, \u22643 vs 3\u20136\u2009months, \u22643 vs &gt;6\u2009months), histotype, and grade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 16\u2009322 patients with pT1b\u20132 RCC treated with nephrectomy, time to surgery &gt;3\u2009months was recorded in 3023 (18%) patients. These patients were older (median age 64 vs 62\u2009years) and harboured a smaller proportion of pT2 patients (19% vs 30%). After one\u2010to\u2010one PSM, 3023 (100%) patients with a time to surgery &gt;3\u2009months exhibited a 60\u2010month CSM of 7.6% vs 5.9% in 3023 (23%) patients with a time to surgery \u22643\u2009months. In CRR time to surgery &gt;3\u2009months independently predicted 1.3\u2010fold higher CSM (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). Subgroup analyses revealed a dose\u2013response effect, with a CSM increase in 1.3\u2010fold fashion when time to surgery was 3\u20136\u2009months vs 1.6\u2010fold fashion when time to surgery was &gt;6\u2009months. The detrimental effect of time to surgery&gt;3\u2009months was consistent across all grades but was not evidenced among patients with a non\u2010clear cell RCC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with pT1b\u20102N0M0 treated with either PN or RN, prolonged time from diagnosis to surgery was associated with higher CSM. This association was not observed among patients with non\u2010clear cell RCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70468","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:36:50Z","timestamp":1790689010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of time to nephrectomy on cancer\u2010specific mortality in pathological T stage (\n                    <scp>pT)1b<\/scp>\n                    \u20132 renal cancer"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7773-5101","authenticated-orcid":false,"given":"Michele","family":"Nicolazzini","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Urology, Department of Translational Medicine Maggiore della Carit\u00e0 Hospital, University of Eastern Piedmont  Novara Italy"},{"name":"Division of Urology, Department of Oncology University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6218-3761","authenticated-orcid":false,"given":"Federico","family":"Polverino","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9523-3400","authenticated-orcid":false,"given":"Leonardo","family":"Quarta","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec 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