{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:03:34Z","timestamp":1790661814289,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to assess whether non\u2010invasive surveillance with computed tomography (CT) urography and urinary cytology could safely reduce the need for ureteroscopy (URS) in patients with upper tract urothelial carcinoma treated with endoscopic kidney\u2010sparing surgery (eKSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We performed a retrospective multicentre analysis of patients undergoing eKSS for upper tract urothelial carcinoma at two tertiary centres (2006\u20132025). Surveillance included second\u2010look URS at 4\u20136\u2009weeks, then every 6\u2009months for 2\u2009years and annually thereafter. CT urography and urinary cytology were performed within 3\u2009months before each URS, and this served as the reference standard. Four trigger strategies were evaluated for diagnostic performance. Analysis started from the third URS. Recurrence over time was analysed using annualized rates per person\u2010year, accounting for multiple recurrences and treating radical nephroureterectomy as a competing event, overall and by risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 133 patients and 256 ureteroscopic assessments were included. Combined CT and\/or cytology showed sensitivity of 35.5%, specificity of 75.0%, a positive predictive value of 64.1% (95% confidence interval [CI] 52.4\u201374.7), and a negative predictive value of 48.0% (95% CI 40.4\u201355.7), avoiding 69.2% of URS (95% CI 63.1\u201374.8) but missing 64.5% of recurrences (95% CI 56.0\u201372.4). Cytology alone was highly specific (97%) but poorly sensitive (11%); CT alone showed moderate sensitivity (27%) and good specificity (78%); requiring both to be positive yielded near\u2010perfect specificity but near\u2010zero sensitivity (2.8%). Recurrence rates were stable across follow\u2010up years at 0.34, 0.35, 0.35, and 0.28 events\/person\u2010year at years 1\u20134 in the low\u2010risk group, and 0.33, 0.38, 0.32, and 0.32 in the high\u2010risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CT urography and urinary cytology may reduce the frequency of URS but cannot safely replace endoscopic surveillance because of the high rate of missed recurrences. Stable recurrence rates over time support the need for continued long\u2010term endoscopic follow\u2010up after eKSS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70469","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:33:43Z","timestamp":1790660023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CT<\/scp>\n                    urography and urinary cytology in surveillance of endoscopically managed\n                    <scp>UTUC<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6126-9889","authenticated-orcid":false,"given":"Pietro","family":"Scilipoti","sequence":"first","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"GRC20\u2010Endolase Lab, Sorbonne University, PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1873-4032","authenticated-orcid":false,"given":"Raffaele La","family":"Mura","sequence":"additional","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"GRC20\u2010Endolase Lab, Sorbonne University, PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5593-5995","authenticated-orcid":false,"given":"Federico","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"GRC20\u2010Endolase Lab, Sorbonne University, PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8759-4652","authenticated-orcid":false,"given":"Marie","family":"Chicaud","sequence":"additional","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"GRC20\u2010Endolase Lab, Sorbonne University, PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Nannola","sequence":"additional","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris France"},{"name":"GRC20\u2010Endolase Lab, Sorbonne University, PIMM\u2010Arts et M\u00e9tiers Paris Tech  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1744-8913","authenticated-orcid":false,"given":"Carlos Gonzalez","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Service d'urologie Tenon H\u00f4pital  Paris 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