{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:55:33Z","timestamp":1790934933322,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["3101\u201000209B"],"award-info":[{"award-number":["3101\u201000209B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"abstract":"\n Objectives<\/jats:title>\n To examine, in a nationally representative Danish study, a comprehensive range of sexual characteristics, dysfunctions and relational challenges among men with prostate cancer (PCa) aged \u226550\u2009years and women married to such men, compared with unaffected men and women.<\/jats:p>\n <\/jats:sec>\n \n Patients\/Subjects and Methods<\/jats:title>\n \n We analysed baseline questionnaire data from the Project SEXUS cohort study (2017\u20132018) for men aged \u226550\u2009years with (\n n<\/jats:italic>\n \u2009=\u2009715) or without (\n n<\/jats:italic>\n \u2009=\u200913\u2009883) a history of PCa, and women married to such men with (\n n<\/jats:italic>\n \u2009=\u2009345) or without (\n n<\/jats:italic>\n \u2009=\u20098323) a history of PCa. In sex\u2010specific analyses, prevalence estimates were calculated for a broad range of sexual and relational outcomes, and logistic regression analyses yielded confounder\u2010adjusted odds ratios (aORs) with 95% confidence intervals (CIs).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Compared with controls without PCa, men with a history of PCa had substantially higher odds of sexual inactivity (aOR 2.03, 95% CI 1.69\u20132.43), unmet sexual needs (aOR 1.89, 95% CI 1.58\u20132.28), poorer self\u2010rated sex life (aOR 1.82, 95% CI 1.46\u20132.28), and sexual dysfunctions, with particularly elevated odds of erectile (aOR 5.74, 95% CI 4.25\u20137.74), orgasmic (aOR 3.20, 95% CI 2.09\u20134.89), and genital pain (aOR 3.07, 95% CI 1.02\u20139.25) dysfunctions. Among women, sexual needs did not differ between the two groups. However, women married to men with PCa were more likely to report sexual inactivity (aOR 1.85, 95% CI 1.42\u20132.39), unmet sexual needs (aOR 1.77, 95% CI 1.34\u20132.34), and poorer marriage quality (aOR 2.84, 95% CI 1.33\u20136.08).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Men with PCa and women married to such men report a substantially increased burden of sexual and relational challenges, underscoring the need for survivorship care that supports sexual well\u2010being in both patients and their intimate partners.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.70475","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:19:53Z","timestamp":1790932793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sexual and relational challenges in men and women affected by prostate cancer: a\n Project SEXUS<\/i>\n study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2605-6566","authenticated-orcid":false,"given":"Ingrid Josefine","family":"Lundorff","sequence":"first","affiliation":[{"name":"Project SEXUS Group, Section of Blood\u2010borne and Sexually Transmitted Infections & Digitization of Infectious Disease Surveillance, Department of Infectious Disease Epidemiology and Prevention Statens Serum Institut Copenhagen Denmark"},{"name":"Center for Sexology Research, Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-3637","authenticated-orcid":false,"given":"Christian","family":"Graugaard","sequence":"additional","affiliation":[{"name":"Center for Sexology Research, Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-4581","authenticated-orcid":false,"given":"Mikkel","family":"Fode","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Urology Copenhagen University Hospital Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-2057","authenticated-orcid":false,"given":"Mikael","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Data Science and AI in Health Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-8860","authenticated-orcid":false,"given":"Morten","family":"Frisch","sequence":"additional","affiliation":[{"name":"Project SEXUS Group, Section of Blood\u2010borne and Sexually Transmitted Infections & Digitization of Infectious Disease Surveillance, Department of Infectious Disease Epidemiology and Prevention Statens Serum Institut Copenhagen Denmark"},{"name":"Center for Sexology Research, Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Global cancer observatory: cancer today","author":"Ferlay J","year":"2024"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa1606221","article-title":"Patient\u2010reported outcomes after monitoring, surgery, or radiotherapy for prostate cancer","volume":"375","author":"Donovan JL","year":"2016","journal-title":"N Engl J Med"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.m3503","article-title":"Fifteen year quality of life outcomes in men with localised prostate cancer: population based Australian prospective study","volume":"7","author":"Mazariego CG","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2471\/BLT.24.291565","article-title":"Associations between sexual health and well\u2010being: a systematic review","volume":"102","author":"Vasconcelos P","year":"2024","journal-title":"Bull World Health Organ"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jsxm.2016.11.324","article-title":"Sexual rehabilitation after treatment for prostate cancer\u2014part 2: recommendations from the fourth international consultation for sexual medicine (ICSM 2015)","volume":"14","author":"Salonia A","year":"2017","journal-title":"J Sex Med"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41443-020-00386-4","article-title":"Neglected side effects to curative prostate cancer treatments","volume":"33","author":"Nols\u00f8e AB","year":"2021","journal-title":"Int J Impot Res"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005392-199707000-00050","article-title":"Factors associated with waning sexual function among elderly men and prostate cancer patients","volume":"158","author":"Helgason AR","year":"1997","journal-title":"J Urol"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/pon.1031","article-title":"Psychosocial adjustment of female partners of men with prostate cancer: a review of the literature","volume":"15","author":"Couper J","year":"2006","journal-title":"Psychooncology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/pon.1449","article-title":"Sexual dysfunction and spousal communication in couples coping with prostate cancer","volume":"18","author":"Badr H","year":"2009","journal-title":"Psychooncology"},{"key":"e_1_2_12_11_1","volume-title":"Sex in Denmark: Key Findings from Project SEXUS 2017\u20132018","author":"Frisch M","year":"2019"},{"issue":"7","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish civil registration system","volume":"39","author":"Pedersen CB","year":"2011","journal-title":"Scand J Public Health"},{"key":"e_1_2_12_13_1","unstructured":"FrischM AnderssonM.Sampling participation drop outs representativity and weighting in connection with the baseline data collection in Project SEXUS 2017\u20132018. 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a study from the cancer registry of Norway","volume":"22","author":"Nilsson M","year":"2024","journal-title":"Clin Genitourin Cancer"},{"key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/jsm.12624","article-title":"Prevalence and predicting factors for commonly neglected sexual side effects to radical prostatectomies: results from a cross\u2010sectional questionnaire\u2010based study","volume":"11","author":"Frey A","year":"2014","journal-title":"J Sex Med"},{"key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jsxm.2017.01.015","article-title":"Prevalence and predicting factors for commonly neglected sexual side effects to external\u2010beam radiation therapy for prostate cancer","volume":"14","author":"Frey A","year":"2017","journal-title":"J Sex Med"},{"key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/bjc.2015.275","article-title":"Patient\u2010reported sexual toxicity after radiation therapy in long\u2010term prostate cancer survivors","volume":"113","author":"Olsson CE","year":"2015","journal-title":"Br J Cancer"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.sxmr.2017.09.003","article-title":"Orgasmic dysfunction following radical prostatectomy: review of current literature","volume":"6","author":"Clavell\u2010Hern\u00e1ndez J","year":"2018","journal-title":"Sex Med Rev"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/pon.657","article-title":"Finding help for sexual problems after prostate cancer treatment: a phone survey of men's and women's perspectives","volume":"12","author":"Neese LE","year":"2003","journal-title":"Psychooncology"},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/COC.0000000000000067","article-title":"Partner's perspective on long\u2010term sexual dysfunction after prostate cancer treatment","volume":"39","author":"Movsas TZ","year":"2016","journal-title":"Am J Clin Oncol"},{"key":"e_1_2_12_30_1","first-page":"2967","article-title":"Couple distress after localised prostate cancer","volume":"21","author":"Chambers SK","year":"2013","journal-title":"Support Care Cancer"},{"key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1743-6109.2005.00148.x","article-title":"Sexual dysfunction in female Partners of men who Have Undergone Radical Prostatectomy Correlates with sexual dysfunction of the male partner","volume":"2","author":"Shindel A","year":"2005","journal-title":"J Sex Med"},{"key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11764-009-0109-y","article-title":"Cancer\u2010related communication, relationship intimacy, and psychological distress among couples coping with localized prostate cancer","volume":"4","author":"Manne S","year":"2010","journal-title":"J Cancer 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