{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:27:25Z","timestamp":1793957245236,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate real\u2010world utilisation of radical cystectomy (RC), its acceptance and limitations, and physician perspectives on RC in patients with high\u2010risk non\u2010muscle\u2010invasive bladder cancer (HR\u2010NMIBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Subjects and Methods<\/jats:title>\n                    <jats:p>Data were obtained from the Adelphi Disease Specific Programme\u2122, a multinational, cross\u2010sectional survey of urologists and medical oncologists treating patients with HR\u2010NMIBC in China, Japan, Canada, France, Germany, Italy, Spain, and the UK. Physicians reported patient demographics, clinical characteristics, treatment patterns, and patient preferences regarding HR\u2010NMIBC treatment and surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 359 physicians provided data for 2583 patients (mean [standard deviation] patient age, 68.9\u2009[9.8]\u2009years; 74% male; Stage\u20101 [T1] high\u2010grade tumours 68%). Bacillus Calmette\u2013Gu\u00e9rin (BCG) was used as first\u2010line treatment in 58% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091487) of patients. Among patients with recurrent HR\u2010NMIBC, RC was used in 8% (62 of 802), 7% (13 of 188), and 8% (four of 52) at second line\u2010of\u2010treatment, third line\u2010of\u2010treatment, and fourth line\u2010of\u2010treatment, respectively. Physicians considered 24% of patients likely future RC candidates. Further data were collected on 825 patients who received BCG treatment. Among these patients, RC was offered to 169 (20%); 115 of these patients (68%) refused, most commonly because of quality\u2010of\u2010life concerns (87%), unwillingness to have a stoma (60%), and surgical safety concerns (37%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite guideline recommendations, real\u2010world RC use was low, and most patients offered RC refused it because of quality\u2010of\u2010life and safety concerns. These findings highlight an unmet need for alternative and efficacious bladder\u2010preserving treatments for patients with BCG\u2010unresponsive HR\u2010NMIBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70480","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:05:44Z","timestamp":1790985944000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world radical cystectomy use in high\u2010risk non\u2010muscle\u2010invasive bladder cancer: a global survey"],"prefix":"10.1111","volume":"138","author":[{"given":"Jose Luis Dominguez","family":"Escrig","sequence":"first","affiliation":[{"name":"Jefe Cl\u00ednico Servicio de Urolog\u00eda Fundaci\u00f3n Instituto Valenciano de Oncolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences University of British Columbia  Vancouver British Columbia Canada"},{"name":"Gordon &amp; Leslie Diamond Health Care Centre &amp; Vancouver General Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6791-905X","authenticated-orcid":false,"given":"Junichi","family":"Inokuchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine University of the Ryukyus  Ginowan Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Division of Urology and Surgical Oncology, Department of Surgery University of Toronto  Toronto Ontario Canada"},{"name":"Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-5587","authenticated-orcid":false,"given":"Wei","family":"Qiang","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Yige","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-9929","authenticated-orcid":false,"given":"Lucy","family":"Andersen","sequence":"additional","affiliation":[{"name":"Market Access Johnson &amp; Johnson  Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Market Access Johnson &amp; Johnson  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhee","family":"Jain","sequence":"additional","affiliation":[{"name":"Market Access Johnson &amp; Johnson  Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0791-2535","authenticated-orcid":false,"given":"Brendan","family":"Osborne","sequence":"additional","affiliation":[{"name":"Medical Affairs Johnson &amp; Johnson  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Deault\u2010Bonin","sequence":"additional","affiliation":[{"name":"Medical Affairs Johnson &amp; Johnson  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobh\u00e1n Mulhern","family":"Haughey","sequence":"additional","affiliation":[{"name":"Market Access Johnson &amp; Johnson  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Biondi","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0807-7401","authenticated-orcid":false,"given":"Laure","family":"Manuel","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Skilling","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Unsworth","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-4026","authenticated-orcid":false,"given":"Christopher J. D.","family":"Wallis","sequence":"additional","affiliation":[{"name":"Division of Urology and Surgical Oncology, Department of Surgery University of Toronto  Toronto Ontario Canada"},{"name":"Division of Urology Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1170124"},{"key":"e_1_2_9_3_1","unstructured":"IARC.Global cancer observatory: cancer today.2025. Available at:https:\/\/gco.iarc.fr\/today\/en\/dataviz. Accessed February 2025"},{"key":"e_1_2_9_4_1","unstructured":"IARC.Global cancer observatory: bladder cancer fact sheet.2025. Available at:https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/30\u2010bladder\u2010fact\u2010sheet.pdf. Accessed February 2025"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02984-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3800"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.02.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.12.033"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144112"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.1196"},{"key":"e_1_2_9_11_1","volume-title":"INLEXZO\u2122 (Gemcitabine Intravesical System) [Package Insert]","author":"Janssen","year":"2025"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.166475"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.7487"},{"key":"e_1_2_9_14_1","unstructured":"EAU.EAU Guidelines. Edn. presented at the EAU Annual Congress Madrid 2025.2025. ISBN 978\u201094\u201092671\u201029\u20105. Available at:https:\/\/d56bochluxqnz.cloudfront.net\/documents\/full\u2010guideline\/EAU\u2010Guidelines\u2010on\u2010Non\u2010muscle\u2010invasive\u2010Bladder\u2010Cancer\u20102025.pdf. Accessed June 2025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.11.012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uro2.35"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.20200602"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2022.12.016"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-025-02887-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.4_suppl.701"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802457040"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003846"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14210"},{"key":"e_1_2_9_24_1","first-page":"S78","article-title":"French ccAFU guidelines \u2013 update 2020\u20132022: bladder cancer","volume":"30","author":"Roupret M","year":"2020","journal-title":"Prog Urol"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09324.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.045"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2020.03.013"},{"key":"e_1_2_9_28_1","first-page":"28","article-title":"Can we lower the rates of cystectomy complications by modifying risk factors? A review of the literature","volume":"75","author":"Hladun T","year":"2022","journal-title":"Cent European J Urol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S341896"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.07.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-1439(03)00144-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2024.05.012"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK-25-471942"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.70480","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:45:21Z","timestamp":1793954721000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.70480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1111\/bju.70480"],"URL":"https:\/\/doi.org\/10.1111\/bju.70480","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"2026-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}