{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:39:29Z","timestamp":1792370369267,"version":"4.4.0"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"abstract":"\n Objectives<\/jats:title>\n To present and describe the design, data collection framework, and interim cohort characteristics of the PENIMA project, a multicentre initiative establishing a clinically annotated penile lesion image repository to support future artificial intelligence (AI)\u2010driven decision\u2010support development \u2013 and to encourage urology and dermatology colleagues working with penile lesions to participate in the project.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n Prospective participant inclusion commenced in March 2023 across Scandinavian urological and dermatological departments. Patients with penile anatomy undergoing clinically indicated genital examination are invited to participate and provide oral and written consent as defined by local authority regulations. Clinical photographs and structured metadata are collected. Lesion classification is based on a specialist evaluation, clinical follow\u2010up and histopathology when available. Images are pseudonymised and annotated using a secure, containerised Computer Vision Annotation Tool (CVAT) environment. Supervised machine\u2010learning model development using convolutional neural networks is planned with patient\u2010level dataset partitioning and evaluation using standard diagnostic performance metrics. The study was approved by relevant local authorities, and the approval number is 1\u201010\u201072\u2010150\u201022.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n As of February 2026, 1125 participants and approximately 7000 images have been included. In all, 40% represented normal anatomical variants. Among lesional cases, 33% are clinically assessed as benign, 13% premalignant, and 8% malignant; 22% of all cases have histopathological verification. Concordance between clinical suspicion and histopathology is highest for penile carcinoma (84.6%, 95% confidence interval 75.0\u201391.0%).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The PENIMA project includes a multicentre, clinically grounded image repository reflecting real\u2010world penile lesion presentations. The feasible and successful infrastructure provides a foundation for future development and validation of image\u2010based clinical decision\u2010support tools.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.70489","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T23:45:36Z","timestamp":1792367136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The PENIMA project<\/scp>\n : artificial intelligence decision\u2010support tool for penile lesions \u2013 protocol paper and invitation to participate"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6880-9281","authenticated-orcid":false,"given":"Janni","family":"M\u00f8lsted","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Urology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Birgitte","family":"Als","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4347-739X","authenticated-orcid":false,"given":"J\u00f8rgen Bjerggaard","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-3127","authenticated-orcid":false,"given":"Mikael","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Anni Larsen","family":"Lethan","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-5574","authenticated-orcid":false,"given":"Sinja","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-0526","authenticated-orcid":false,"given":"Christian Arvei","family":"Moen","sequence":"additional","affiliation":[{"name":"Department of Urology Haukeland University Hospital Bergen Norway"},{"name":"Department of Clinical Medicine University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-5078","authenticated-orcid":false,"given":"Axel","family":"Gerdtsson","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University Lund 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