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In recent years, the mechanisms by which RNA\u2010binding proteins regulate reproductive development and gametogenesis have emerged as a focal point in mitochondrial biology. Here, we review the latest progresses on the role of mitochondrial translation and its associated ribosomal regulation in sperm formation and activation. In <jats:italic>Caenorhabditis elegans<\/jats:italic>, the RNA\u2010binding protein complex AMG\u20101\/SLRP\u20101 modulates key processes of sperm development by maintaining mitochondrial homeostasis. Furthermore, we explore the distinct roles of mitochondrial translation and metabolic functions in sperm activation and motility. This review summarizes the mechanisms by which mitochondrial ribosomal regulation governs spermatogenesis and sperm function, offering a foundation for future investigations in reproductive biology.<\/jats:p>","DOI":"10.1111\/boc.12007","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:39:47Z","timestamp":1741711187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mitochondrial Ribosome Regulation Drives Spermatogenesis and Male Fertility"],"prefix":"10.1111","volume":"117","author":[{"given":"Zhanxin","family":"Chang","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Cell Proliferation and Regulation Biology College of Life Science Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Miao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Cell Proliferation and Regulation Biology College of Life Science Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of RNA Biology CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing 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