{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:19:23Z","timestamp":1784240363050,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>In this review, we present multi\u2010scale mathematical models of ovarian follicular development that are based on the embedding of physiological mechanisms into the cell scale. During basal follicular development, follicular growth operates through an increase in the oocyte size concomitant with the proliferation of its surrounding granulosa cells. We have developed a spatio\u2010temporal model of follicular morphogenesis explaining how the interactions between the oocyte and granulosa cells need to be properly balanced to shape the follicle. During terminal follicular development, the ovulatory follicle is selected amongst a cohort of simultaneously growing follicles. To address this process of follicle selection, we have developed a model giving a continuous and deterministic description of follicle development, adapted to high numbers of cells and based on the dynamical and hormonally regulated repartition of granulosa cells into different cell states, namely proliferation, differentiation and apoptosis. This model takes into account the hormonal feedback loop involving the growing ovarian follicles and the pituitary gland, and enables the exploration of mechanisms regulating the number of ovulations at each ovarian cycle. Both models are useful for addressing ovarian physio\u2010pathological situations. Moreover, they can be proposed as generic modelling environments to study various developmental processes and cell interaction mechanisms.<\/jats:p>","DOI":"10.1111\/boc.201500087","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T09:08:43Z","timestamp":1455008923000},"page":"149-160","source":"Crossref","is-referenced-by-count":33,"title":["Multi\u2010scale modelling of ovarian follicular development: From follicular morphogenesis to selection for ovulation"],"prefix":"10.1111","volume":"108","author":[{"given":"Danielle","family":"Monniaux","sequence":"first","affiliation":[{"name":"INRA UMR85 Physiologie de la Reproduction et des Comportements  Nouzilly F\u201037380 France"},{"name":"CNRS UMR7247  Nouzilly F\u201037380 France"},{"name":"Universit\u00e9 Fran\u00e7ois Rabelais de Tours  Tours F\u201037041 France"},{"name":"IFCE  Nouzilly F\u201037380 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Michel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon CNRS UMR5208 Ecole Centrale de Lyon Institut Camille Jordan  Ecully Cedex 69134 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Postel","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 06 UMR7598 Laboratoire Jacques\u2010Louis Lions  Paris F\u201075005 France"},{"name":"Project\u2010team Mycenae Centre Inria de Paris  75589 Paris Cedex\u00a012 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"Project\u2010team Mycenae Centre Inria de Paris  75589 Paris Cedex\u00a012 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1051\/proc\/201238006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1137\/120904238"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1000203"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod49.5.895"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-5564(98)10026-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1137\/120862247"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.1997.tb00939.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1137\/120897249"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2012.12.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.1.E35"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1631-0691(02)01457-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1120379"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-10-0485"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.036400"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/383531a0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2005.05.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.13.6.0310"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1551"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-4-20"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1770435"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.3.648"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/77033"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm040"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.3.638"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-17-2-121"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3042"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(00)75033-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1230613"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y10-009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1150251"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.2.0394"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9686-37-S1-S25"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2004.08.013"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1137\/090745738"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.07.046"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.117077"},{"key":"e_1_2_7_38_1","first-page":"3","article-title":"Follicular growth and ovarian dynamics in mammals","volume":"51","author":"Monniaux D.","year":"1997","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091577598"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.08.001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122066899"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:2000133"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1010501"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.082941"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.033"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD09161"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmaa.2013.01.001"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0729"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11903"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0840105"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.058529"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-4-19"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.082016"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0720153"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1071\/BI9770229"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.4.1225"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.09.023"}],"container-title":["Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fboc.201500087","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.201500087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:08:28Z","timestamp":1696288108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/boc.201500087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,29]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/boc.201500087"],"URL":"https:\/\/doi.org\/10.1111\/boc.201500087","archive":["Portico"],"relation":{},"ISSN":["0248-4900","1768-322X"],"issn-type":[{"value":"0248-4900","type":"print"},{"value":"1768-322X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,29]]}}}