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Over the past two decades, multiple studies involving cell cultures, animal models and human subjects have established the importance of the protein kinase RNA\u2010like endoplasmic reticulum kinase (PERK) in the adaptive functional capacity of pancreatic \u03b2\u00a0cells during embryonic development and into adulthood. In this review, we will highlight major findings identifying PERK as a crucial player in \u03b2\u00a0cell physiology and in diabetes.<\/jats:p>","DOI":"10.1111\/boc.201700059","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T07:52:44Z","timestamp":1511423564000},"page":"27-32","source":"Crossref","is-referenced-by-count":15,"title":["PERK leads a hub dictating pancreatic \u03b2\u00a0cell homoeostasis"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-9688","authenticated-orcid":false,"given":"George","family":"Kefalas","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine Department of Medicine McGill University and the Research Institute of McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9491","authenticated-orcid":false,"given":"Louise","family":"Larose","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine Department of Medicine McGill University and the Research Institute of McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3109"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.06.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.071498"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0701"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81294-5"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429772"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.20.7198-7209.2003"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314219200"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/78085"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-10-61"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01009-12"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1064"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2738"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00108-8"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80330-5"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00264-7"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.428987"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-11-59"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0197"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-8-38"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.1.76"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-29"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0590-z"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.11.008"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2604-3"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131012"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214550"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00265-9"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1259"},{"key":"e_1_2_13_31_1","article-title":"Inhibition of the sarco\/endoplasmic reticulum (ER) Ca2+\u2010ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response","author":"Sehgal P.","year":"2017","journal-title":"J. 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