{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:39:29Z","timestamp":1792453169048,"version":"4.5.0"},"reference-count":71,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204957\/Z\/16\/Z"],"award-info":[{"award-number":["204957\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection with <jats:italic>Mycobacterium ulcerans<\/jats:italic> results in a necrotising skin disease known as a Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin mycolactone. Recent studies have identified the protein translocation machinery of the endoplasmic reticulum (ER) membrane as the primary cellular target of mycolactone, and shown that the toxin binds to the core subunit of the Sec61 complex. Mycolactone binding strongly inhibits the capacity of the Sec61 translocon to transport newly synthesised membrane and secretory proteins into and across the ER membrane. Since the ER acts as the entry point for the mammalian secretory pathway, and hence regulates initial access to the entire endomembrane system, mycolactone\u2010treated cells have a reduced ability to produce a range of proteins including secretory cytokines and plasma membrane receptors. The global effect of this molecular blockade of protein translocation at the ER is that the host is unable to mount an effective immune response to the underlying mycobacterial infection. Prolonged exposure to mycolactone is normally cytotoxic, since it triggers stress responses activating the transcription factor ATF4 and ultimately inducing apoptosis.<\/jats:p>","DOI":"10.1111\/boc.201800030","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T07:27:15Z","timestamp":1532849235000},"page":"237-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7848-586X","authenticated-orcid":false,"given":"Caroline","family":"Demangel","sequence":"first","affiliation":[{"name":"Immunobiology of Infection Unit Institut Pasteur  Paris France"},{"name":"INSERM  U1221 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"High","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Function School of Biological Sciences Faculty of Biology Medicine and Health University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916654144"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160662"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004450"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00053"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902854"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20160045"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201102542"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070234"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.054494"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004808"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2077"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01588-07"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3182-3186.2005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.93"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003066"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.13.159"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5403.854"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.877-883.2000"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02712-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1704-1707.2001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050375"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705242114"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0906.020485"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016496108"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66576"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab0458"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004061"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.122"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000325"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006058"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643426"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.12.008"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.165746"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12308"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015252108"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00887"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005972"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01483"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.040"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.182352"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.198655"},{"key":"e_1_2_8_44_1","article-title":"Proteomics reveals scope of mycolactone\u2010mediated Sec61 blockade and distinctive stress signature","volume":"18","author":"Morel J.\u2010D.","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61962-0"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006814"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104649"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005011"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0427-y"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.04.008"},{"key":"e_1_2_8_51_1","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.4049\/jimmunol.163.7.3928","article-title":"The inhibitory action of Mycobacterium ulcerans soluble factor on monocyte\/T cell cytokine production and NF\u2010kappa B function","volume":"163","author":"Pahlevan A.A.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1086\/646615"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002786"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.958-965.2004"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2743-2"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1370530"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2017.836"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001237"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-202"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12547"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802294"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0882-4010(02)00210-3"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9070227"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305877101"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005553"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.06.006"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68807-7"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130100"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.12.1.125-129.2005"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1005581"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04206.x"},{"key":"e_1_2_8_72_1","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00045-17","article-title":"Buruli ulcer, a prototype for ecosystem\u2010related infection, caused by Mycobacterium ulcerans","volume":"31","author":"Zingue D.","year":"2018","journal-title":"Clin. Microbiol. Rev."}],"container-title":["Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fboc.201800030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.201800030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T05:19:16Z","timestamp":1694927956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/boc.201800030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,14]]},"references-count":71,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/boc.201800030"],"URL":"https:\/\/doi.org\/10.1111\/boc.201800030","archive":["Portico"],"relation":{},"ISSN":["0248-4900","1768-322X"],"issn-type":[{"value":"0248-4900","type":"print"},{"value":"1768-322X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,14]]},"assertion":[{"value":"2018-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}