{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:44:21Z","timestamp":1790829861377,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015613","name":"Centre hospitalier r\u00e9gional universitaire de Lille","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["6041"],"award-info":[{"award-number":["6041"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010095","name":"R\u00e9gion Hauts-de-France","doi-asserted-by":"publisher","award":["CPER Cancer 2007\u20102013"],"award-info":[{"award-number":["CPER Cancer 2007\u20102013"]}],"id":[{"id":"10.13039\/501100010095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010095","name":"R\u00e9gion Hauts-de-France","doi-asserted-by":"publisher","award":["CPER Cancer 2015\u20102020"],"award-info":[{"award-number":["CPER Cancer 2015\u20102020"]}],"id":[{"id":"10.13039\/501100010095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015872","name":"Universit\u00e9 de Lille","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background Information<\/jats:title>\n                    <jats:p>Although improvements have been made in the management of pancreatic adenocarcinoma (PDAC) during the past 20 years, the prognosis of this deadly disease remains poor with an overall 5\u2010year survival under 10%. Treatment with FOLFIRINOX, a combined regimen of 5\u2010fluorouracil, irinotecan (SN\u201038) and oxaliplatin, is nonetheless associated with an excellent initial tumour response and its use has allowed numerous patients to go through surgery while their tumour was initially considered unresectable. These discrepancies between initial tumour response and very low long\u2010term survival are the consequences of rapidly acquired chemoresistance and represent a major therapeutic frontier. To our knowledge, a model of resistance to the combined three drugs has never been described due to the difficulty of modelling the FOLFIRINOX protocol both in vitro and in vivo. Patient\u2010derived tumour organoids (PDO) are the missing link that has long been lacking in the wide range of epithelial cancer models between 2D adherent cultures and in vivo xenografts. In this work we sought to set up a model of PDO with resistance to FOLFIRINOX regimen that we could compare to the paired naive PDO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We first extrapolated physiological concentrations of the three drugs using previous pharmacodynamics studies and bi\u2010compartmental elimination models of oxaliplatin and SN\u201038. We then treated PaTa\u20101818x naive PDAC organoids with six cycles of 72 h\u2010FOLFIRINOX treatment followed by 96 h interruption. Thereafter, we systematically compared treated organoids to PaTa\u20101818x naive organoids in terms of growth, proliferation, viability and expression of genes involved in cancer stemness and aggressiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We reproductively obtained resistant organoids FoxR that significantly showed less sensitivity to FOLFORINOX treatment than the PaTa\u20101818x naive organoids from which they were derived. Our resistant model is representative of the sequential steps of chemoresistance observed in patients in terms of growth arrest (proliferation blockade), residual disease (cell quiescence\/dormancy) and relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>To our knowledge, this is the first genuine in vitro model of resistance to the three drugs in combined therapy. This new PDO model will be a great asset for the discovery of acquired chemoresistance mechanisms, knowledge that is mandatory before offering new therapeutic strategies for pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/boc.202100003","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T01:25:59Z","timestamp":1632533159000},"page":"32-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A new pancreatic adenocarcinoma\u2010derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms"],"prefix":"10.1111","volume":"114","author":[{"given":"Elsa","family":"Hadj Bachir","sequence":"first","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Poiraud","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"},{"name":"Department of Digestive Surgery and Transplantation CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Paget","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Stoup","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"El Moghrabi","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Duch\u00eane","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Jouy","sequence":"additional","affiliation":[{"name":"UMS 2014 \u2013 US 41 \u2013 PLBS \u2013 Plateformes Lilloises en Biologie &amp; Sant\u00e9 BioImaging Center Lille (BICeL) Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"UMS 2014 \u2013 US 41 \u2013 PLBS \u2013 Plateformes Lilloises en Biologie &amp; Sant\u00e9 BioImaging Center Lille (BICeL) Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Tardivel","sequence":"additional","affiliation":[{"name":"UMS 2014 \u2013 US 41 \u2013 PLBS \u2013 Plateformes Lilloises en Biologie &amp; Sant\u00e9 BioImaging Center Lille (BICeL) Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis\u2010Bastien","family":"Weiswald","sequence":"additional","affiliation":[{"name":"UNICAEN Inserm U1086 ANTICIPE \u201cInterdisciplinary Research Unit for Cancer Prevention and Treatment\u201d Normandie Univ  Caen France"},{"name":"Cancer Centre F. Baclesse UNICANCER  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vandepeutte","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Beugniez","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"},{"name":"Department of Digestive Surgery and Transplantation CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Escande","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology CHU Lille Hormonology Metabolism Nutrition Oncology  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Leteurtre","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"},{"name":"Department of Pathology CHU Lille Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"OrgaRES consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Poulain","sequence":"additional","affiliation":[{"name":"UNICAEN Inserm U1086 ANTICIPE \u201cInterdisciplinary Research Unit for Cancer Prevention and Treatment\u201d Normandie Univ  Caen France"},{"name":"Cancer Centre F. Baclesse UNICANCER  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chann","family":"Lagadec","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pigny","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Jonckheere","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Renaud","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"},{"name":"Department of Pathology CHU Lille Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Truant","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"},{"name":"Department of Digestive Surgery and Transplantation CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Van Seuningen","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Vincent","sequence":"additional","affiliation":[{"name":"CNRS, Inserm, CHU Lille, UMR9020\u2010U1277 \u2010 CANTHER \u2013 Cancer Heterogeneity Plasticity and Resistance to Therapies Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2067","article-title":"In vitro activation of irinotecan to SN\u201038 by human liver and intestine","volume":"19","author":"Ahmed F.","year":"1999","journal-title":"Anticancer Research"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.20.3771"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.02.038"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.15.27"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2016.03.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1261-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112362"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","unstructured":"Beumer J.&Clevers H.(2016)Regulation and plasticity of intestinal stem cells during homeostasis and regeneration.3639\u20133649.","DOI":"10.1242\/dev.133132"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019101654"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.143"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.01.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809775"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0644-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.08.2023"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-018-3722-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23090"},{"key":"e_1_2_7_20_1","first-page":"2761","article-title":"Pancreatic cancer stem cells and therapeutic approaches","volume":"37","author":"Ercan G.","year":"2017","journal-title":"Anticancer Research"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-13-92"},{"issue":"1","key":"e_1_2_7_22_1","first-page":"113","article-title":"Article ampk is a negative regulator of the warburg effect and suppresses tumor growth in vivo","volume":"17","author":"Faubert B.","year":"2013","journal-title":"CMET"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010020\u20100754\u20100"},{"key":"e_1_2_7_24_1","first-page":"9","article-title":"Cell cycle perturbation and acquired 5\u2010fluorouracil chemoresistance","volume":"28","author":"Guo X.","year":"2008","journal-title":"Anticancer Research"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171301998"},{"key":"e_1_2_7_26_1","first-page":"1","article-title":"Long\u2010term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis","author":"Hof L.","year":"2021","journal-title":"Bmc Biology"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.204"},{"issue":"17","key":"e_1_2_7_28_1","first-page":"3976","article-title":"Specific proteolytic cleavage of Poly(ADP\u2010ribose) polymerase: an early marker of chemotherapy\u2010induced apoptosis","volume":"53","author":"Kaufmann S.H.","year":"1993","journal-title":"Cancer Research"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000097"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.479"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.02.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0440"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856001300248353"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30974-0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4342"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2019.0284"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0329"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2018.06.005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.21614\/jtmr-21-4-100"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3590"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/920161"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2017.12.005"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-18-0531"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.63"},{"issue":"1","key":"e_1_2_7_46_1","first-page":"45","article-title":"Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation","volume":"160","author":"Rosty C.","year":"2002","journal-title":"AJP"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13533"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6145"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.1.105"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101372"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.06.004"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.179"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3414"},{"issue":"14","key":"e_1_2_7_54_1","first-page":"1719","article-title":"Regulation of cyclin E1 expression in human pluripotent stem cells and derived neural progeny","volume":"17","author":"Soledad M.","year":"2018","journal-title":"Cell Cycle"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12332"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01452-3"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-3062"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.02.007"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2012"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00208"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2016.07.002"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-009084"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-010-9249-2"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-103390"},{"issue":"2","key":"e_1_2_7_65_1","first-page":"168","article-title":"Pancreatic cancer: An overview","volume":"11","author":"Vincent A.","year":"2011","journal-title":"Lancet"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.2.353"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaj2227"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0196-z"}],"container-title":["Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.202100003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/boc.202100003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.202100003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:56:58Z","timestamp":1692759418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/boc.202100003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,16]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/boc.202100003"],"URL":"https:\/\/doi.org\/10.1111\/boc.202100003","archive":["Portico"],"relation":{},"ISSN":["0248-4900","1768-322X"],"issn-type":[{"value":"0248-4900","type":"print"},{"value":"1768-322X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,16]]},"assertion":[{"value":"2021-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}