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A large number of mutations particularly in the LMNA gene encoding lamin A\/C results in a wide array of human diseases, collectively termed as laminopathies. Dilated Cardiomyopathy (DCM) is one such laminopathic cardiovascular disease which is associated with systolic dysfunction of left or both ventricles leading to cardiac arrhythmia which ultimately culminates into myocardial infarction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this work, we have unraveled the epigenetic landscape to address the regulation of gene expression in mouse myoblast cell line in the context of the missense mutation LMNA 289A&lt;G (Lys97Glu) that is found in DCM\u2010afflicted patient with severe symptoms. Significant changes in H3\u2010specific epigenetic modifications indicated a dysregulation in transcription machinery which was investigated by RNA sequencing analysis. The major pathways involved in IL\u201017 signaling, cellular response to interferon\u2010beta and gamma, cytokine production, and related pathways are found to be downregulated. Analysis of the promoter sequences of the genes in the abovementioned pathways led us to the master regulator NF\u2010\u03baB and its regulatory network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report here for the first time that there is a significant downregulation of the NF\u2010\u03baB pathway, which has been implicated in cardio\u2010protection elsewhere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/boc.202300094","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T06:23:41Z","timestamp":1708928621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lamin A K97E leads to NF\u2010\u03baB\u2010mediated dysfunction of inflammatory responses in dilated 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