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Gonadotoxic treatments, such as chemotherapy and radiation therapy, have significantly improved the survival rates of cancer patients but have also been shown to have adverse effects on the testicular microenvironment. Therefore, repairing the testicular niche after gonadotoxic treatments is essential to restore its function. In recent years, several approaches, such as stem cell transplantation, gene therapy, growth factor therapy, and pharmacological interventions have been proposed as potential therapeutic strategies to repair the testicular niche. This comprehensive review aims to provide an overview of the current understanding of testis damage and repair mechanisms. We will cover a range of topics, including the mechanism of gonadotoxic action, repair mechanisms, and treatment approaches. Overall, this review highlights the importance of repairing the testicular niche after gonadotoxic treatments and identifies potential avenues for future research to improve the outcomes for cancer survivors.<\/jats:p>","DOI":"10.1111\/boc.202300123","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T13:14:11Z","timestamp":1710249251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Testicular niche repair after gonadotoxic treatments: Current knowledge and future directions"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2813-3986","authenticated-orcid":false,"given":"Amirhossein","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Stem Cell and Regenerative Medicine Research Center Iran University of Medical Sciences  Tehran Iran"},{"name":"Department of Anatomy School of Medicine Iran University of Medical Sciences  Tehran 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