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Carbohydrate\u2010based polymers (CBPs) restore testis differentiation and downregulate apoptosis genes. CBP has biodegradability, low cost, and wide availability, but is at risk of contamination and variations. CBP shows promise in wound healing, but more research is required before implementation in healthcare. Herein, we discuss the recent advances in engineering applications of CBP employed as scaffolds, drug delivery systems, immunomodulation, and stem cell therapy for testicular regeneration. Moreover, we emphasize the promising challenges warranted for future perspectives.<\/jats:p>","DOI":"10.1111\/boc.202400013","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T05:40:43Z","timestamp":1718602843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Using carbohydrate\u2010based polymers to facilitate testicular regeneration"],"prefix":"10.1111","volume":"116","author":[{"given":"Aneeqa","family":"Majeed","sequence":"first","affiliation":[{"name":"Applied Molecular Biology and Biomedicine Lab Department of Zoology, University of Narowal  Narowal Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-7497","authenticated-orcid":false,"given":"Hanan","family":"Afzal","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Cancer Therapeutics Lab Department of Zoology Faculty of Sciences &amp; Technology University of Central Punjab  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaleem","family":"Maqsood","sequence":"additional","affiliation":[{"name":"Institute of Zoology University of the Punjab  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amara","family":"Noureen","sequence":"additional","affiliation":[{"name":"Applied Molecular Biology and Biomedicine Lab Department of Zoology, University of Narowal  Narowal Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaman","family":"Gul","sequence":"additional","affiliation":[{"name":"Institute of Zoology University of the Punjab  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[{"name":"Center of Applied Molecular Biology University of the Punjab  Lahore 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