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Despite the growth of multiple topics regarding fine\u2010tuning homeobox gene expression, the discussion on how the circadian rhythm affects their control and vice\u2010versa still needs to be improved. Due to the intrinsic importance of the circadian clock and its impact on several molecular mechanisms, including development and pregnancy, the interplay between this mechanism and homeobox genes becomes a meaningful discussion. This work aims to review and critically discuss the crosstalk between homeobox genes and circadian regulation in multiple organisms, focusing on differentiation and developmental mechanisms. 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