{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:01:36Z","timestamp":1784552496375,"version":"3.55.0"},"reference-count":126,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Two isoforms of the 90\u2010kDa heat shock protein (Hsp90), stress\u2010inducible Hsp90\u03b1 and constitutively expressed Hsp90\u03b2, function in mammalian cells as molecular chaperones that promote the folding of specific client proteins involved in essential cellular processes and regulatory pathways. A number of Hsp90 client proteins take part in cancer progression, and the inhibition of Hsp90 induces the degradation of oncogenic client proteins and cancer cell death. Hsp90 inhibitors specific for individual Hsp90 isoforms have a significant potential for the development of anticancer therapeutics due to reduced toxicity. Cells with knocked\u2010out genes encoding Hsp90 isoforms represent excellent cellular models to investigate the rearrangement of the cell chaperone machinery in response to the suppression\/loss of the Hsp90 isoforms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recently, we have shown that the knockout of the HSP90AA1 gene encoding Hsp90\u03b1 in human fibrosarcoma HT1080 cells does not affect basic cellular processes in normal and stressful conditions, which suggests an adaptation of the cell chaperone machinery to the loss of Hsp90\u03b1. Here, we demonstrated that the lack of Hsp90\u03b1 in HT1080 cells leads to an up\u2010regulation of the constitutively expressed Hsp90\u03b2 and several important Hsp90 co\u2010chaperones (Aha1, Hop, and others). The expression of the major chaperones of the Hsp70 machinery (Hsp70\u20101, Hsp70\u20102, Hsc70) was also significantly induced. The components of the prefoldin\u2010chaperonin folding arm and PFDL, R2TP, and R2SP complexes, as well as the major mitochondrial chaperones, were also largely up\u2010regulated in Hsp90\u03b1\u2010KO cells, while the expression of ER\u2010resident chaperones\/co\u2010chaperones was either repressed or did not change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Significance<\/jats:title>\n                    <jats:p>We demonstrated here for the first time an adaptation of the cell chaperone machinery to the loss of the Hsp90\u03b1 chaperone, which may be important for understanding the molecular mechanisms of action of Hsp90\u03b1\u2010specific inhibitors and elaborating new therapy strategies in combating cancer, including the combination of Hsp90\u03b1\u2010targeted therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/boc.70064","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:22:12Z","timestamp":1777699332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rearrangement of the Cell Chaperone Machinery in Human Fibrosarcoma HT1080 Cells With the Knocked\u2010Out\n                    <i>HSP90AA1<\/i>\n                    Gene Encoding Hsp90\u03b1"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-5554","authenticated-orcid":false,"given":"Viktoria","family":"Petrenko","sequence":"first","affiliation":[{"name":"Institute of Cell Biophysics Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d  Pushchino Moscow Region Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Vrublevskaya","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d  Pushchino Moscow Region Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Skarga","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d  Pushchino Moscow Region Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Zhmurina","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d  Pushchino Moscow Region Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Morenkov","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d  Pushchino Moscow Region Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2938"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.11.039"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102010\u201011\u201010\u2010r106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710063200"},{"key":"e_1_2_10_7_1","unstructured":"Andrews S.2010.FastQC: A Quality Control Tool for High Throughput Sequence Data. Available online at:http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00801"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV120.011833"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.11.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906\u20106705.2004.00114.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100409\u20103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033916\u20103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115080"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a034017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1521\u20101878(199911)21:11<932::aid\u2010bies5>3.0.co;2\u2010n"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E13\u201002\u20100106"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.18494"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2015.00010"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.09.042"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2461"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.217661"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20190198"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020277"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.52.35194"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000640\u20109"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100531200"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20605"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/celldisc.2016.2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cstres.2025.100118"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1131"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15528.1"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010013\u20100413\u20103"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M900415\u2010MCP200"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.03.002"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015770"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.026"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a040281"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068408"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(95)90099\u20103"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.76"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2017.11.001"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010011\u20100285\u20103"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2020.1752227"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msad169"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.146845"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010020\u20100740\u20107"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.2012646"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010018\u20100948\u20104"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2941"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010008\u20100068\u20107"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201025404\u2010w"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_10_54_1","unstructured":"Krueger F.2012.A Wrapper Tool Around Cutadapt and FastQC to Consistently Apply Quality and Adapter Trimming to FastQ Files. Babraham Bioinformatics.https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/trim_galore\/."},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.09.003"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.09.009"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.03.004"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2022.8443"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom2010143"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl7295"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.04.013"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3969"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4063"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12081045"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12091166"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2004.01.021"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024792\u20104"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004431\u20101"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.02.022"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.8.1.371\u2010380.1988"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202015422"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2015.00022"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010micro\u2010020518\u2010115515"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo\u2010reports\/kve246"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.760413"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.01.006"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1379\/1466\u20101268(2003)008<0125:cotcdr>2.0.co;2"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.9.1.27"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m009745200"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102443.2001.00447.x"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.3.JNS081146"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.09.022"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201700231"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3678"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/341125a0"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010022\u201002765\u2010x"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097\u20102765(02)00785\u20102"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.06.076"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.022"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.21767\/2471\u20108084.100030"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010016\u20100676\u20106"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.021"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cstres.2024.05.005"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.10.006"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2017.05.016"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010019\u20100133\u20103"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.20"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201006\u20100650"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00724"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2857"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020597\u2010z"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m600891200"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010071"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.102666"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.2344"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.10.4250\u20104261.2005"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.788463"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509497200"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.12.025"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.12579"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2918"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M400055\u2010MCP200"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(00)81446\u20104"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5105"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.1.1"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800007200"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts356"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010025\u201000890\u20109"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201022885\u20108"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1716"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201040204\u20104_6"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.110447"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.083"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.375"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.06.018"}],"container-title":["Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.70064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/boc.70064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.70064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:02:30Z","timestamp":1784548950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/boc.70064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":126,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/boc.70064"],"URL":"https:\/\/doi.org\/10.1111\/boc.70064","archive":["Portico"],"relation":{},"ISSN":["0248-4900","1768-322X"],"issn-type":[{"value":"0248-4900","type":"print"},{"value":"1768-322X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70064"}}