{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:01:40Z","timestamp":1784552500109,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n \n Pancreatic islet\n \u03b4<\/jats:italic>\n \u2010cells produce somatostatin, a paracrine regulator of insulin and glucagon secretion within islets. Although adaptive changes in\n \u03b1<\/jats:italic>\n \u2010 and\n \u03b2<\/jats:italic>\n \u2010cell populations during pregnancy have been described in both animals and humans, data on\n \u03b4<\/jats:italic>\n \u2010cell plasticity are sparse and entirely lacking in human pregnancy. We aimed to determine whether pancreatic islet\n \u03b4<\/jats:italic>\n \u2010cell mass undergoes morphological adaptation during human pregnancy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n Formalin\u2010fixed paraffin\u2010embedded pancreatic tissue from pregnant (\n n<\/jats:italic>\n = 7) and non\u2010pregnant (\n n<\/jats:italic>\n = 7) donors was analysed. Sections were immunolabelled for somatostatin to identify\n \u03b4<\/jats:italic>\n cells, and whole\u2010slide quantitative analysis was performed using an unbiased automated imaging pipeline.\n \u03b4<\/jats:italic>\n \u2010cell area was measured across the entire pancreatic sections and compared between groups. In contrast to previously reported expansion of\n \u03b1<\/jats:italic>\n \u2010 and\n \u03b2<\/jats:italic>\n \u2010cell populations in pregnancy,\n \u03b4<\/jats:italic>\n \u2010cell area was not significantly different between pregnant and non\u2010pregnant donors. No quantitative architectural alterations in\n \u03b4<\/jats:italic>\n \u2010cell distribution within islets were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Pancreatic\n \u03b4<\/jats:italic>\n \u2010cell area does not increase during human pregnancy. These findings demonstrate that endocrine cell plasticity within the maternal pancreas is selective and does not uniformly involve all islet cell subtypes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/boc.70067","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:12:28Z","timestamp":1778058748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delta\u2010Cell Area is Unchanged in Human Pregnancy: Evidence From Immunohistochemistry"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-6015","authenticated-orcid":false,"given":"Faheem","family":"Seedat","sequence":"first","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine University of Oxford Oxford UK"},{"name":"Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neva","family":"Kandzija","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Drydale","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Holden","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bancroft","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Todd","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Irina","family":"Stefana","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Vatish","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics, Nuffield Department of Medicine University of Oxford Oxford UK"},{"name":"Nuffield Department of Women's and Reproductive Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1809-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2316"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106439"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.10.046"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25074070"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05213-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4881-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0923"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281082"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61852-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.01.015"}],"container-title":["Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.70067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/boc.70067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/boc.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:02:32Z","timestamp":1784548952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/boc.70067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/boc.70067"],"URL":"https:\/\/doi.org\/10.1111\/boc.70067","archive":["Portico"],"relation":{},"ISSN":["0248-4900","1768-322X"],"issn-type":[{"value":"0248-4900","type":"print"},{"value":"1768-322X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70067"}}