{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:58:05Z","timestamp":1790780285051,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010CE13\u20100006"],"award-info":[{"award-number":["ANR\u201017\u2010CE13\u20100006"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lamin A is a major contributor to nuclear mechanics and an important mediator of mechanotransduction. While its role in regulating nuclear architecture is well established, considerably less attention has been given to how mechanical cues regulate lamin A itself. Here, we review current evidence demonstrating that lamin A homeostasis is dynamically controlled by mechanical stimulation through transcriptional, translational, and post\u2010translational mechanisms regulating protein abundance, stability, and turnover. We further discuss emerging evidence suggesting that prelamin A maturation, a highly conserved multistep processing pathway, may represent a previously unrecognized mechanosensitive regulatory node. Recent studies challenge the canonical model of prelamin A processing and raise the possibility of alternative maturation pathways with important implications for lamin A homeostasis. We highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases.<\/jats:p>","DOI":"10.1111\/boc.70080","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:20:37Z","timestamp":1790778037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis"],"prefix":"10.1111","volume":"118","author":[{"given":"Sandrine","family":"Fraboulet","sequence":"first","affiliation":[{"name":"Institute for Advanced Biosciences University Grenoble Alpes INSERM U1209\u2010CNRS UMR 5309  La Tronche France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Aldarawish","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences University Grenoble Alpes INSERM U1209\u2010CNRS UMR 5309  La Tronche France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-4709","authenticated-orcid":false,"given":"Monika Elzbieta","family":"Dolega","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences University Grenoble Alpes INSERM U1209\u2010CNRS UMR 5309  La Tronche France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2016.10.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948084"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010025\u201003201\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083410"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13374"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032120"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.122995"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.11.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873\u20103468.14750"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.07.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43578"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/19491034.2016.1150397"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101073"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.12.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63284","article-title":"A Small\u2010Molecule ICMT Inhibitor Delays Senescence of Hutchinson\u2010Gilford Progeria Syndrome Cells","volume":"10","author":"Chen X.","year":"2021","journal-title":"eLife"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.04.020"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702226114"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.128835"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509124"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.24.15030"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2022.01.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad7297"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000488\u2010w"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25439"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0092-8674(90)90471-P","article-title":"In Vitro Disassembly of the Nuclear Lamina and M Phase\u2010Specific Phosphorylation of Lamins by cdc2 Kinase","volume":"61","author":"Dotie M. 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