{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:58:45Z","timestamp":1790675925111,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201022\u2010CE13\u20100037"],"award-info":[{"award-number":["ANR\u201022\u2010CE13\u20100037"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The mammalian vestibular system has two types of sensory receptor hair cells (HCs), each with different neurotransmission mechanisms. Type II HCs use ribbon synapses to transmit neurotransmitters like glutamate to bouton terminals of afferent neurons. Type I HCs are nearly engulfed by a calyceal afferent ending. They regulate afferent activity through both quantal and non\u2010quantal transmission (NQT), the latter faster than classic neurotransmitter release and potentially key to stabilizing vision and balance during rapid head movements. Here, we describe a novel striated contact, present only in the mouse type I HC and its calyceal afferent ending. Electron tomography reveals periodic striations on both the HC and calyx plasma membranes. These contact sites are intimately associated with a plasma membrane mitochondria contact site on the type I HC side of the synapse. Given that mitochondrion\u2013plasma membrane contact sites in other systems regulate local ion homeostasis, this distinctive arrangement has the potential to serve or modulate NQT at the type I HC\u2013calyx synapse.<\/jats:p>","DOI":"10.1111\/boc.70082","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:19:07Z","timestamp":1790673547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Striated Membrane Contact Site in Vestibular Hair Cells"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-0164","authenticated-orcid":false,"given":"Nicolas","family":"Brouilly","sequence":"first","affiliation":[{"name":"IBDM, Institut de Biologie du D\u00e9veloppement de Marseille Aix Marseille Univ  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-3197","authenticated-orcid":false,"given":"Nathalie","family":"Pujol","sequence":"additional","affiliation":[{"name":"CIML, Aix Marseille Univ, INSERM, CNRS Turing Centre for Living Systems  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2748-8797","authenticated-orcid":false,"given":"Fabrice","family":"Richard","sequence":"additional","affiliation":[{"name":"IBDM, Institut de Biologie du D\u00e9veloppement de Marseille Aix Marseille Univ  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Cazevieille","sequence":"additional","affiliation":[{"name":"INM, Institut des Neurosciences de Montpellier INSERM\u2010Universit\u00e9 de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-0590","authenticated-orcid":false,"given":"Jennifer","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, and the Virginia Merrill Bloedel Hearing Research Center University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-2051","authenticated-orcid":false,"given":"Ruth Anne","family":"Eatock","sequence":"additional","affiliation":[{"name":"Department of Neurobiology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-7129","authenticated-orcid":false,"given":"R\u00e9my","family":"Pujol","sequence":"additional","affiliation":[{"name":"INM, Institut des Neurosciences de Montpellier INSERM\u2010Universit\u00e9 de Montpellier  Montpellier France"},{"name":"Department of Otolaryngology\/Head and Neck Surgery, and the Virginia Merrill Bloedel Hearing Research Center University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"ilastik: Interactive Machine Learning for (bio)Image Analysis","volume":"16","author":"Berg S.","year":"2019","journal-title":"Nature Methods"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.22\u201014\u201005840.2002"},{"key":"e_1_2_6_4_1","article-title":"Mitochondria\u2010Plasma Membrane Contact Sites: Emerging Regulators of Mitochondrial Form and Function","volume":"8","author":"Casler J. 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A.","year":"2023","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1113\/JP278680","article-title":"Synaptic Cleft Microenvironment Influences Potassium Permeation and Synaptic Transmission in Hair Cells Surrounded by Calyx Afferents in the Turtle","volume":"598","author":"Contini D.","year":"2020","journal-title":"Journal of Physiology"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrn.2017.170","article-title":"Mitochondria at the Neuronal Presynapse in Health and Disease","volume":"19","author":"Devine M. J.","year":"2018","journal-title":"Nature Reviews Neuroscience"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/bs.ctdb.2025.07.001","article-title":"Functional Development and Differentiation of Mammalian Vestibular Hair Cells and Their Synapses","volume":"165","author":"Eatock R. 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