{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:08:59Z","timestamp":1757542139277},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Suprasellar tumors with compression of the optic chiasm are associated with an impaired sleep\u2013wake rhythm. We hypothesized that this reflects a disorder of the biological clock of the human brain, the suprachiasmatic nucleus (<jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content>), which is located just above the optic chiasm. In order to test this hypothesis, we investigated the expression of two key neuropeptides of the <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content>, that is, arginine vasopressin (<jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content>) and vasoactive intestinal peptide (<jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content>), as assessed by quantitative immunocytochemistry in post\u2010mortem hypothalamic tissue of patients with a suprasellar tumor inducing permanent visual field defects. Post\u2010mortem hypothalamic tissue of 5 patients with a suprasellar tumor inducing permanent visual field defects (acromegaly n\u2009=\u20092, nonfunctioning macro\u2010adenoma n\u2009=\u20091, macroprolactinoma n\u2009=\u20091, infundibular metastasis of a colorectal adenocarcinoma n\u2009=\u20091) and 15 age\u2010 and gender\u2010matched controls was obtained from the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etherlands Brain Bank. Total <jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content> immunoreactivity in the <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> was lower in patients with a suprasellar tumor than in controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). By contrast, total <jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content> immunoreactivity was not different between patients and controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.44). Suprasellar tumors leading to permanent visual field defects are associated with reduced <jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content>, but not <jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content> immunoreactivity, in the <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content>. These findings raise the possibility that selective impairment of the <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content> contributes to sleep\u2013wake disturbances in these patients.<\/jats:p>","DOI":"10.1111\/bpa.12016","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T04:04:33Z","timestamp":1356149073000},"page":"440-444","source":"Crossref","is-referenced-by-count":11,"title":["Arginine Vasopressin Immunoreactivity is Decreased in the Hypothalamic Suprachiasmatic Nucleus of Subjects with Suprasellar Tumors"],"prefix":"10.1111","volume":"23","author":[{"given":"Anke J.","family":"Borgers","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Fliers","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline E.","family":"Siljee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick F.","family":"Swaab","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatric Disorders Netherlands Institute for Neuroscience Institute of the Royal Netherlands Academy of Arts and Sciences  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eus J. 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