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On magnetic resosnance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), the tumors generally appeared solid and non\u2010contrast enhancing with minimal diffuse infiltration, edema, or mass effect. Six examples demonstrated internal nodularity. Microscopically, the tumor cells were largely distributed into discrete and coalescent nodules exhibiting varying degrees of matrix vacuolization, principally within the deep cortical ribbon and superficial subcortical white matter. Populating elements ranged from morphologically ambiguous to recognizably neuronal, with only two cases manifesting overt ganglion cell cytology. In all cases, tumor cells exhibited widespread nuclear immunolabeling for the<jats:styled-content style=\"fixed-case\">HuC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HuD<\/jats:styled-content>neuronal antigens, although expression of other neuronal markers, including synaptophysin, neurofilament and chromogranin was variable to absent. Tumor cells also failed to express<jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>, p53,<jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>132<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>, or<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34, although<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\u2010labeling ramified neural elements were present in the adjoining cortex of seven cases. Molecular analysis in a subset of cases failed to reveal<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>copy number abnormalities or<jats:styled-content style=\"fixed-case\">BRAF V<\/jats:styled-content>600<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mutation. Follow\u2010up data indicate that this unusual neuronal lesion behaves in benign, World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) grade<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>fashion and is amenable to surgical control.<\/jats:p>","DOI":"10.1111\/bpa.12035","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T09:06:40Z","timestamp":1358413600000},"page":"515-524","source":"Crossref","is-referenced-by-count":139,"title":["Multinodular and Vacuolating Neuronal Tumors of the Cerebrum: 10 Cases of a Distinctive Seizure\u2010Associated Lesion"],"prefix":"10.1111","volume":"23","author":[{"given":"Jason T.","family":"Huse","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Edgar","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Medical Center Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Halliday","sequence":"additional","affiliation":[{"name":"Gerstner Sloan\u2010Kettering Graduate School Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Mikolaenko","sequence":"additional","affiliation":[{"name":"New York University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Lavi","sequence":"additional","affiliation":[{"name":"New York\u2010Presbyterian Hospital of Weill Cornell Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc K.","family":"Rosenblum","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480280108"},{"key":"e_1_2_7_3_1","first-page":"103","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Becker AJ","year":"2007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051017"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19990701)46:1<53::AID-JEMT5>3.0.CO;2-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.7.575"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.2.175"},{"key":"e_1_2_7_8_1","first-page":"209","article-title":"Tumors of the central nervous system. 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