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This changed with the discovery of <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010immunoglobulin G (<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>), a specific autoantibody which was detected in the vast majority of <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> patients, and with the demonstration that this autoantibody targets aquaporin 4 (<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4), a water channel found on astrocytes in the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>. These findings paved the way for the generation of experimental models of <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>. 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