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Here, we report a case involving a 22\u2010year\u2010old man with a right occipital lobe tumor, which comprised mainly epithelioid tumor cells with a small area of diffusely infiltrating less atypical astrocytoma cells showing a lower cell density. Array comparative genomic hybridization separately performed for each histologically distinct component demonstrated eight shared copy number alterations (<jats:styled-content style=\"fixed-case\">CNAs<\/jats:styled-content>) and three <jats:styled-content style=\"fixed-case\">CNAs<\/jats:styled-content> observed only in epithelioid cells; one of the latter was a homozygous deletion of a tumor suppressor gene, <jats:styled-content style=\"fixed-case\"><jats:italic>LSAMP<\/jats:italic><\/jats:styled-content>, at 3q13.31. <jats:styled-content style=\"fixed-case\"><jats:italic>BRAF<\/jats:italic> V<\/jats:styled-content>600<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> mutation was observed both in epithelioid tumor cells and in diffusely infiltrating less atypical astrocytoma cells. Our findings suggest that the regional loss of <jats:styled-content style=\"fixed-case\"><jats:italic>LSAMP<\/jats:italic><\/jats:styled-content> led to the aggressive nature of epithelioid cells in the present case of epithelioid glioblastoma.<\/jats:p>","DOI":"10.1111\/bpa.12114","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T10:12:40Z","timestamp":1386929560000},"page":"239-246","source":"Crossref","is-referenced-by-count":35,"title":["Intratumoral Heterogeneity of Genomic Imbalance in a Case of Epithelioid Glioblastoma with <scp><i>BRAF<\/i> V<\/scp>600<scp>E<\/scp> Mutation"],"prefix":"10.1111","volume":"24","author":[{"given":"Sumihito","family":"Nobusawa","sequence":"first","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Hirato","sequence":"additional","affiliation":[{"name":"Department of 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