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Schwannomas have a variety of morphological appearances, but they behave as World Health Organization (\n                    <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\n                    ) grade\n                    <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                    tumors, and only very rarely undergo malignant transformation. Central to the pathogenesis of these tumors is loss of function of merlin, either by direct genetic change involving the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>NF<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>2<\/jats:italic>\n                    gene on chromosome 22 or secondarily to merlin inactivation. The genetic pathways and morphological features of schwannomas associated with different genetic syndromes will be discussed. Merlin has multiple functions, including within the nucleus and at the cell membrane, and this review summarizes our current understanding of the mechanisms by which merlin loss is involved in schwannoma pathogenesis, highlighting potential areas for therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1111\/bpa.12125","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T02:42:28Z","timestamp":1390444948000},"page":"205-220","source":"Crossref","is-referenced-by-count":264,"title":["Schwannomas and Their Pathogenesis"],"prefix":"10.1111","volume":"24","author":[{"given":"David A.","family":"Hilton","sequence":"first","affiliation":[{"name":"Department of Cellular and Anatomical Pathology Derriford Hospital  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens Oliver","family":"Hanemann","sequence":"additional","affiliation":[{"name":"Institute of Translational and Stratified Medicine Plymouth University 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