{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:47:36Z","timestamp":1790718456659,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Municipal Health Bureau 215 project","award":["No. 2011-3-095"],"award-info":[{"award-number":["No. 2011-3-095"]}]},{"name":"German Research Foundation ( EpiGenNet)","award":["DFG Bl421\/3-1"],"award-info":[{"award-number":["DFG Bl421\/3-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>\n \n S<\/jats:styled-content>\n turge\u2013\n W<\/jats:styled-content>\n eber syndrome (\n SWS<\/jats:styled-content>\n ) is a rare syndrome characterized by capillary\u2010venous malformations involving skin and brain. Many patients with\n SWS<\/jats:styled-content>\n also suffer from drug\u2010resistant epilepsy. We retrospectively studied a series of six\n SWS<\/jats:styled-content>\n patients with epilepsy and extensive neurosurgical resections. At time of surgery, the patients' age ranged from 11 to 35 years (with a mean of 20.2 years). All surgical specimens were well preserved, which allowed a systematic microscopical inspection utilizing the 2011\n ILAE<\/jats:styled-content>\n classification for focal cortical dysplasia (\n FCD<\/jats:styled-content>\n ). Neuropathology revealed dysmorphic\u2010like neurons with hypertrophic cell bodies reminiscent to those described for\n FCD<\/jats:styled-content>\n type\n IIa<\/jats:styled-content>\n in all cases. However, gross architectural abnormalities of neocortical layering typical for\n FCD<\/jats:styled-content>\n type\n IIa<\/jats:styled-content>\n were missing, and we propose to classify this pattern as\n FCD ILAE<\/jats:styled-content>\n type\n IIIc<\/jats:styled-content>\n . In addition, our patients with earliest seizure onset also showed polymicrogyria (\n PMG<\/jats:styled-content>\n ; n\u2009=\u20094). The ictal onset zones were identified in all patients by subdural electrodes, and these areas always showed histopathological evidence for\n FCD<\/jats:styled-content>\n type\n IIIc<\/jats:styled-content>\n . Four out of five patients had favorable seizure control after surgery with a mean follow\u2010up period of 1.7 years. We concluded from our study that\n FCD<\/jats:styled-content>\n type\n IIIc<\/jats:styled-content>\n and\n PMG<\/jats:styled-content>\n are frequently associated findings in\n SWS<\/jats:styled-content>\n .\n FCD<\/jats:styled-content>\n type\n IIIc<\/jats:styled-content>\n may play a major epileptogenic role in\n SWS<\/jats:styled-content>\n and complete resection of the associated\n FCD<\/jats:styled-content>\n should be considered a prognostic key factor to achieve seizure control.\n <\/jats:p>","DOI":"10.1111\/bpa.12172","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T07:12:48Z","timestamp":1405667568000},"page":"248-255","source":"Crossref","is-referenced-by-count":33,"title":["S<\/scp>\n turge\u2013\n W<\/scp>\n eber Syndrome Is Associated with Cortical Dysplasia\n ILAE<\/scp>\n Type\n IIIc<\/scp>\n and Excessive Hypertrophic Pyramidal Neurons in Brain Resections for Intractable Epilepsy"],"prefix":"10.1111","volume":"25","author":[{"given":"Dan\u2010Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"Bl\u00fcmcke","sequence":"additional","affiliation":[{"name":"Department of Neuropathology University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Coras","sequence":"additional","affiliation":[{"name":"Department of Neuropathology University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tsinghua University Yuquan Hospital Beijing 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