{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:44:15Z","timestamp":1791902655118,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#5T32CA163185"],"award-info":[{"award-number":["#5T32CA163185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50CA127001"],"award-info":[{"award-number":["P50CA127001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Pathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>orld <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>rganization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) grading of meningioma stratifies patients according to recurrence risk overall, there is substantial within\u2010grade heterogeneity with respect to recurrence\u2010free survival (<jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content>). Most meningiomas are graded according to mitotic counts per unit area on hematoxylin and eosin sections, a method potentially confounded by tumor cellularity, as well as potential limitations of accurate mitotic figure detection on routine histology. To refine mitotic figure assessment, we evaluated 363 meningiomas with phospho\u2010histone <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>3 (Ser10) and determined the mitotic index (number of mitoses per 1000 tumor cells). The median mitotic indices among <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> grade <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (n\u2009=\u2009268), grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (n\u2009=\u200984) and grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (n\u2009=\u200911) tumors were 1, 4 and 12. Classification and regression tree analysis to categorize cut\u2010offs identified three subgroups defined by mitotic indices of 0\u20132, 3\u20134 and\u2009\u22655, which on univariate analysis were associated with <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In multivariate analysis, mitotic index subgrouped in this manner was significantly associated with <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) after adjustment for Simpson grade, <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> grade and <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 index. Mitotic index was then examined within individual <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> grade, showing that for grade <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> meningiomas, mitotic index can add additional information to <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> risk. The results suggest that the use of a robust mitotic marker in meningioma could refine risk stratification.<\/jats:p>","DOI":"10.1111\/bpa.12174","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T11:12:49Z","timestamp":1405681969000},"page":"266-275","source":"Crossref","is-referenced-by-count":111,"title":["Mitotic Index is an Independent Predictor of Recurrence\u2010Free Survival in Meningioma"],"prefix":"10.1111","volume":"25","author":[{"given":"Adriana","family":"Olar","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalida M.","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik P.","family":"Sulman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Toronto Western Hospital University of Toronto  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Zadeh","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Toronto Western Hospital University of Toronto  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine D.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"DeMonte","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory N.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Aldape","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Ontario Cancer Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2010.09.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950050303"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000330399.55586.63"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.27119"},{"key":"e_1_2_8_7_1","volume-title":"Classification and Regression Trees","author":"Breiman L","year":"1983"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181cf7cc1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not325"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-009-0249-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181d7ce6f"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-43"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.12.JNS12414"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-013-1923-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004120050256"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.38.24470"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10351"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12127"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-970554"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-006-0039-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1309\/HXUNAG34B3CEFDU8"},{"key":"e_1_2_8_22_1","volume-title":"WHO Classification of Tumors of the Central Nervous System","author":"Louis DN","year":"2007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050458"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2012.52.1.14"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00006"},{"key":"e_1_2_8_26_1","unstructured":"NCCN(2014)Clinical Practice Guidelines in Oncology. 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